Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson's syndrome.
J Thromb Thrombolysis
; 52(4): 1043-1046, 2021 Nov.
Article
in English
| MEDLINE | ID: covidwho-1525570
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required. METHODS/RESULTS:
By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson's syndrome (catastrophic antiphospholipid syndrome).CONCLUSION:
A parallelism between this severe form of COVID-19 and Asherson's syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Lupus Coagulation Inhibitor
/
Antiphospholipid Syndrome
/
COVID-19
/
Thromboinflammation
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
J Thromb Thrombolysis
Journal subject:
Vascular Diseases
Year:
2021
Document Type:
Article
Affiliation country:
S11239-021-02444-0
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