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Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China.
Zeng, Ling-Kong; Zhu, Hua-Ping; Xiao, Tian-Tian; Peng, Si-Cong; Yuan, Wen-Hao; Shao, Jian-Bo; Wang, Lai-Shuan; Xiao, Fei-Fan; Xia, Shi-Wen; Lee, Shoo K; Yan, Kai; Zhou, Wen-Hao.
  • Zeng LK; Department of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhu HP; Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
  • Xiao TT; National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Peng SC; Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Yuan WH; Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
  • Shao JB; Department of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang LS; Department of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiao FF; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Xia SW; National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Lee SK; Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
  • Yan K; Maternal-Infant Care Research Center (MiCARE) and Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada. shoo.lee@sinaihealthsystem.ca.
  • Zhou WH; Department of Pediatrics, Department of Obstetrics and Gynecology and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. shoo.lee@sinaihealthsystem.ca.
World J Pediatr ; 17(3): 253-262, 2021 06.
Article in English | MEDLINE | ID: covidwho-1176425
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain development.

METHODS:

This multicenter observational study was conducted at two designated maternal and children's hospitals in Hubei Province, mainland China from February 1, 2020 to May 15, 2020. Neonates born to mothers with COVID-19 were enrolled. Brain magnetic resonance imaging (MRI) findings, and volumes of grey and white matters, and physical growth parameters were observed at 44 weeks corrected gestational age.

RESULTS:

Of 72 neonates born to mothers with COVID-19, 8 (11%) were diagnosed with COVID-19, 8 (11%) were critically ill, and no deaths were reported. Among the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks, five neonates were diagnosed with COVID-19. Among these five neonates, three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2, delayed myelination and brain dysplasia in newborn 3, and abnormal signal in the bilateral periventricular in newborn 5. The other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age (P > 0.05). Physical growth parameters for weight, length, and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all neonates.

CONCLUSIONS:

Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical growth. These findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2, but further study is required to evaluate the association between the abnormal MRI findings and the exposure to SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Magnetic Resonance Imaging / Infectious Disease Transmission, Vertical / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: World J Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: S12519-021-00426-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Magnetic Resonance Imaging / Infectious Disease Transmission, Vertical / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: World J Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: S12519-021-00426-z