Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue.
Biofactors
; 47(2): 232-241, 2021 Mar.
Article
in English
| MEDLINE | ID: covidwho-1178977
ABSTRACT
COVID-19 leads to severe respiratory problems, but also to long-COVID syndrome associated primarily with cognitive dysfunction and fatigue. Long-COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS). The pathogenesis of brain fog in these illnesses is presently unknown but may involve neuroinflammation via mast cells stimulated by pathogenic and stress stimuli to release mediators that activate microglia and lead to inflammation in the hypothalamus. These processes could be mitigated by phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Luteolin
/
Fatigue
/
Cognitive Dysfunction
/
COVID-19 Drug Treatment
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Biofactors
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Biof.1726
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