COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin.

Mansoor, Tarab; Alsarah, Ali A; Mousavi, Hossein; Khader Eliyas, Javed; Girotra, Tarun; Hussein, Omar

Mansoor, Tarab; Alsarah, Ali A; Mousavi, Hossein; Khader Eliyas, Javed; Girotra, Tarun; Hussein, Omar.

Mansoor T; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Alsarah AA; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Mousavi H; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Khader Eliyas J; University of New Mexico, Department of Neurosurgery, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Girotra T; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Hussein O; University of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA. Electronic address: ohussein@salud.unm.edu.

J Stroke Cerebrovasc Dis ; 30(7): 105822, 2021 Jul.

Article in English | MEDLINE | ID: covidwho-1179851

ABSTRACT

ABSTRACT

There have been limited cases linking SARS-CoV-2 infection with the development of reversible cerebral vasoconstriction syndrome (RCVS). We hereby report a rare case of RCVS in the setting of mild SARS-CoV-2 respiratory infection successfully treated with nimodipine and aspirin. SARS-CoV-2 attacks the ACE2-receptors, which are expressed in various body organs including the lungs, kidneys, and blood vessels. Vasoconstriction can result from down-regulation of the ACE2-receptors that can lead to sympathetic hypertonia of the cerebral blood vessel walls and/or over-activation of the renin-angiotensin axis.

Subject(s)

Aspirin/therapeutic use; COVID-19/complications; Cerebral Arteries/drug effects; Nimodipine/therapeutic use; Vasoconstriction/drug effects; Vasodilator Agents/therapeutic use; Vasospasm, Intracranial/drug therapy; Adult; COVID-19/diagnosis; Cerebral Arteries/diagnostic imaging; Cerebral Arteries/physiopathology; Female; Humans; Syndrome; Treatment Outcome; Vasospasm, Intracranial/diagnostic imaging; Vasospasm, Intracranial/etiology; Vasospasm, Intracranial/physiopathology

Keywords

Aspirin; COVID-19; Nimodipine; Posterior reversible encephalopathy syndrome; Reversible cerebral vasoconstriction syndrome; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vasoconstriction / Vasodilator Agents / Nimodipine / Cerebral Arteries / Aspirin / Vasospasm, Intracranial / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Stroke Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2021 Document Type: Article Affiliation country: J.jstrokecerebrovasdis.2021.105822

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