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Is procalcitonin a part of human immunological response to SARS-CoV-2 infection or "just" a marker of bacterial coinfection?
Lugito, Nata Pratama Hardjo.
  • Lugito NPH; Department of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman, Lippo Karawaci, Tangerang, Banten 15811, Indonesia. Electronic address: nata.lugito@uph.edu.
Curr Res Transl Med ; 69(2): 103289, 2021 05.
Article in English | MEDLINE | ID: covidwho-1179993
Semantic information from SemMedBD (by NLM)
1. Procalcitonin measurement DIAGNOSES COVID-19
Subject
Procalcitonin measurement
Predicate
DIAGNOSES
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. STAT3 gene|STAT3 STIMULATES Biochemical Pathway
Subject
STAT3 gene|STAT3
Predicate
STIMULATES
Object
Biochemical Pathway
4. Monocytes LOCATION_OF 2019 novel coronavirus
Subject
Monocytes
Predicate
LOCATION_OF
Object
2019 novel coronavirus
5. Procalcitonin measurement DIAGNOSES COVID-19
Subject
Procalcitonin measurement
Predicate
DIAGNOSES
Object
COVID-19
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. STAT3 gene|STAT3 STIMULATES Biochemical Pathway
Subject
STAT3 gene|STAT3
Predicate
STIMULATES
Object
Biochemical Pathway
8. Monocytes LOCATION_OF 2019 novel coronavirus
Subject
Monocytes
Predicate
LOCATION_OF
Object
2019 novel coronavirus
ABSTRACT
Elevated PCT level in COVID-19 was associated with higher risk of severe disease and higher risk of overall mortality. An increased PCT level of PCT in COVID-19 patients especially in severe cases would be assumed as bacterial coinfection. Could PCT level increase in SARS-CoV-2 infection without bacterial coinfection? Several SARS-CoV-2 proteins activate STAT3-dependent transcriptional pathways particularly in monocytes, that could lead to increased PCT production. STAT3α isoform could cause increased ACE2 expression, resulting more SARS-CoV-2 infected cells and further production of PCT.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Bacterial Infections / Coinfection / Procalcitonin / SARS-CoV-2 / COVID-19 Subject: Bacterial Infections / Coinfection / Procalcitonin / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Language: English Journal: Curr Res Transl Med Clinical aspect: Diagnosis / Etiology / Prediction / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Bacterial Infections / Coinfection / Procalcitonin / SARS-CoV-2 / COVID-19 Subject: Bacterial Infections / Coinfection / Procalcitonin / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Language: English Journal: Curr Res Transl Med Clinical aspect: Diagnosis / Etiology / Prediction / Prognosis Year: 2021
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