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The laboratory tests and host immunity of COVID-19 patients with different severity of illness.
Wang, Feng; Hou, Hongyan; Luo, Ying; Tang, Guoxing; Wu, Shiji; Huang, Min; Liu, Weiyong; Zhu, Yaowu; Lin, Qun; Mao, Liyan; Fang, Minghao; Zhang, Huilan; Sun, Ziyong.
  • Wang F; Department of Laboratory Medicine.
  • Hou H; Department of Laboratory Medicine.
  • Luo Y; Department of Laboratory Medicine.
  • Tang G; Department of Laboratory Medicine.
  • Wu S; Department of Laboratory Medicine.
  • Huang M; Department of Laboratory Medicine.
  • Liu W; Department of Laboratory Medicine.
  • Zhu Y; Department of Laboratory Medicine.
  • Lin Q; Department of Laboratory Medicine.
  • Mao L; Department of Laboratory Medicine.
  • Fang M; Department of Emergency Medicine, and.
  • Zhang H; Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Sun Z; Department of Laboratory Medicine.
JCI Insight ; 5(10)2020 05 21.
Article in English | MEDLINE | ID: covidwho-118074
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. 2019 novel coronavirus INTERACTS_WITH COVID-19
Subject
2019 novel coronavirus
Predicate
INTERACTS_WITH
Object
COVID-19
3. Immunity PROCESS_OF Patients
Subject
Immunity
Predicate
PROCESS_OF
Object
Patients
4. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
5. Ferritin AUGMENTS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Ferritin
Predicate
AUGMENTS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
6. Fibrin fragment D AUGMENTS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Fibrin fragment D
Predicate
AUGMENTS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
7. Lactate Dehydrogenase AUGMENTS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Lactate Dehydrogenase
Predicate
AUGMENTS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
8. CD45R PRODUCES C4048280|920
Subject
CD45R
Predicate
PRODUCES
Object
C4048280|920
9. Patients LOCATION_OF interleukin-6
Subject
Patients
Predicate
LOCATION_OF
Object
interleukin-6
10. Patients LOCATION_OF Interleukin 2 Receptor
Subject
Patients
Predicate
LOCATION_OF
Object
Interleukin 2 Receptor
11. Patients LOCATION_OF interleukin-10
Subject
Patients
Predicate
LOCATION_OF
Object
interleukin-10
12. physiological aspects PROCESS_OF Patients
Subject
physiological aspects
Predicate
PROCESS_OF
Object
Patients
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. 2019 novel coronavirus INTERACTS_WITH COVID-19
Subject
2019 novel coronavirus
Predicate
INTERACTS_WITH
Object
COVID-19
15. Immunity PROCESS_OF Patients
Subject
Immunity
Predicate
PROCESS_OF
Object
Patients
16. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
17. Ferritin AUGMENTS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Ferritin
Predicate
AUGMENTS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
18. Fibrin fragment D AUGMENTS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Fibrin fragment D
Predicate
AUGMENTS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
19. Lactate Dehydrogenase AUGMENTS Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Lactate Dehydrogenase
Predicate
AUGMENTS
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
20. CD45RO, human PRODUCES T-Cell Surface Glycoprotein CD4, human|CD4
Subject
CD45RO, human
Predicate
PRODUCES
Object
T-Cell Surface Glycoprotein CD4, human|CD4
21. Patients LOCATION_OF interleukin-6
Subject
Patients
Predicate
LOCATION_OF
Object
interleukin-6
22. Patients LOCATION_OF Interleukin 2 Receptor
Subject
Patients
Predicate
LOCATION_OF
Object
Interleukin 2 Receptor
23. Patients LOCATION_OF interleukin-10
Subject
Patients
Predicate
LOCATION_OF
Object
interleukin-10
24. physiological aspects PROCESS_OF Patients
Subject
physiological aspects
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
BACKGROUNDThe coronavirus disease 2019 (COVID-19), infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a severe outbreak throughout the world. The host immunity of COVID-19 patients is unknown.METHODSThe routine laboratory tests and host immunity in COVID-19 patients with different severity of illness were compared after patient admission.RESULTSA total of 65 SARS-CoV-2-positive patients were classified as having mild (n = 30), severe (n = 20), and extremely severe (n = 15) illness. Many routine laboratory tests, such as ferritin, lactate dehydrogenase, and D-dimer, were increased in severe and extremely severe patients. The absolute numbers of CD4+ T cells, CD8+ T cells, and B cells were gradually decreased with increased severity of illness. The activation markers such as HLA-DR and CD45RO expressed on CD4+ and CD8+ T cells were increased in severe and extremely severe patients compared with mild patients. The costimulatory molecule CD28 had opposite results. The percentage of natural Tregs was decreased in extremely severe patients. The percentage of IFN-γ-producing CD8+ T cells was increased in both severe and extremely severe patients compared with mild patients. The percentage of IFN-γ-producing CD4+ T cells was increased in extremely severe patients. IL-2R, IL-6, and IL-10 were all increased in extremely severe patients. The activation of DC and B cells was decreased in extremely severe patients.CONCLUSIONThe number and function of T cells are inconsistent in COVID-19 patients. The hyperfunction of CD4+ and CD8+ T cells is associated with the pathogenesis of extremely severe SARS-CoV-2 infection.FUNDINGThis work was funded by the National Mega Project on Major Infectious Disease Prevention (2017ZX10103005-007) and the Fundamental Research Funds for the Central Universities (2019kfyRCPY098).
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Limits: Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Limits: Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article