Mental disorders, psychopharmacological treatments, and mortality in 2150 COVID-19 Spanish inpatients.
Acta Psychiatr Scand
; 143(6): 526-534, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1180758
ABSTRACT
OBJECTIVE:
To determine how mental disorders and psychopharmacological treatments before and during COVID-19 hospital admissions are related to mortality.METHODS:
Subjects included in the study were all adult patients with a diagnosis of COVID-19, confirmed clinically and by PCR, who were admitted to a tertiary university hospital in Badalona (Spain) between March 1 and November 17, 2020. Data were extracted anonymously from computerized clinical records.RESULTS:
2,150 subjects were included, 57% males, mean age 61 years. History of mental disorders was registered in 957 (45%). Throughout admission, de novo diagnosis of mood or anxiety, stress, or adjustment disorder was made in 12% of patients without previous history. Delirium was diagnosed in 10% of cases. 1011 patients (47%) received a psychotropic prescription during admission (36% benzodiazepines, 22% antidepressants, and 21% antipsychotics). Mortality rate was 17%. Delirium during admission and history of mood disorder were independently associated with higher mortality risk (hazard ratios, 1.39 and 1.52 respectively), while previous year's treatments with anxiolytics/hypnotics and antidepressants were independently associated with lower mortality risk (hazard ratios, 0.47 and 0.43, respectively).CONCLUSION:
Mental symptoms are very common in patients hospitalized for COVID-19 infection. Detecting, diagnosing, and treating them is key to determining the prognosis of the disease and functional recovery.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Psychotropic Drugs
/
COVID-19
/
Inpatients
/
Mental Disorders
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Qualitative research
Limits:
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
Acta Psychiatr Scand
Year:
2021
Document Type:
Article
Affiliation country:
Acps.13304
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