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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues.
Yang, Fan; Nielsen, Sandra C A; Hoh, Ramona A; Röltgen, Katharina; Wirz, Oliver Fabian; Haraguchi, Emily; Jean, Grace H; Lee, Ji-Yeun; Pham, Tho D; Jackson, Katherine J L; Roskin, Krishna M; Liu, Yi; Nguyen, Khoa; Ohgami, Robert S; Osborne, Eleanor M; Nadeau, Kari C; Niemann, Claus U; Parsonnet, Julie; Boyd, Scott D.
  • Yang F; Department of Pathology, Stanford University, Stanford, CA 94305, USA. sboyd1@stanford.edu fyang90@stanford.edu.
  • Nielsen SCA; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Hoh RA; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Röltgen K; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Wirz OF; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Haraguchi E; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Jean GH; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Lee JY; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Pham TD; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Jackson KJL; Stanford Blood Center, Stanford University, Stanford, CA 94305, USA.
  • Roskin KM; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
  • Liu Y; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45267, USA.
  • Nguyen K; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Ohgami RS; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Osborne EM; Calico Life Sciences, South San Francisco, CA 94080, USA.
  • Nadeau KC; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Niemann CU; Department of Pathology, University of California, San Francisco, CA 94143, USA.
  • Parsonnet J; Sarah Cannon Cancer Center, Tennessee Oncology, Smyrna, TN 37167, USA.
  • Boyd SD; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA 94305, USA.
Science ; 372(6543): 738-741, 2021 05 14.
Article in English | MEDLINE | ID: covidwho-1180894
Semantic information from SemMedBD (by NLM)
1. B-Lymphocytes LOCATION_OF Clonal Evolution
Subject
B-Lymphocytes
Predicate
LOCATION_OF
Object
Clonal Evolution
2. Blood PART_OF Adult
Subject
Blood
Predicate
PART_OF
Object
Adult
3. Cessation of life PROCESS_OF organ donor
Subject
Cessation of life
Predicate
PROCESS_OF
Object
organ donor
4. Gene PART_OF C0162326
Subject
Gene
Predicate
PART_OF
Object
C0162326
5. B-Lymphocytes LOCATION_OF Clonal Evolution
Subject
B-Lymphocytes
Predicate
LOCATION_OF
Object
Clonal Evolution
6. Blood PART_OF Adult
Subject
Blood
Predicate
PART_OF
Object
Adult
7. Cessation of life PROCESS_OF organ donor
Subject
Cessation of life
Predicate
PROCESS_OF
Object
organ donor
8. Genes, Immunoglobulin PART_OF DNA Sequence
Subject
Genes, Immunoglobulin
Predicate
PART_OF
Object
DNA Sequence
ABSTRACT
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, prepandemic children had class-switched convergent clones to severe acute respiratory syndrome coronavirus 2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. These results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Coronavirus / SARS-CoV-2 / Immunologic Memory / Antibodies, Viral Type of study: Randomized controlled trials Topics: Vaccines Limits: Adolescent / Adult / Aged / Child, preschool / Female / Humans / Infant / Male / Middle aged / Young adult Language: English Journal: Science Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Coronavirus / SARS-CoV-2 / Immunologic Memory / Antibodies, Viral Type of study: Randomized controlled trials Topics: Vaccines Limits: Adolescent / Adult / Aged / Child, preschool / Female / Humans / Infant / Male / Middle aged / Young adult Language: English Journal: Science Year: 2021 Document Type: Article