Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants.
Sci Rep
; 11(1): 8021, 2021 04 13.
Article
in English
| MEDLINE | ID: covidwho-1182870
ABSTRACT
At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunoglobulin G
/
SARS-CoV-2
/
COVID-19
/
Maternal-Fetal Exchange
/
Antibodies, Viral
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Sci Rep
Year:
2021
Document Type:
Article
Affiliation country:
S41598-021-87535-x
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