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The importance of genomic analysis in cracking the coronavirus pandemic.
Zella, Davide; Giovanetti, Marta; Cella, Eleonora; Borsetti, Alessandra; Ciotti, Marco; Ceccarelli, Giancarlo; D'Ettorre, Gabriella; Pezzuto, Aldo; Tambone, Vittoradolfo; Campanozzi, Laura; Magheri, Marco; Unali, Francesco; Bianchi, Martina; Benedetti, Francesca; Pascarella, Stefano; Angeletti, Silvia; Ciccozzi, Massimo.
  • Zella D; Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, USA.
  • Giovanetti M; , Member of the Global Virus Network, Baltimore, USA.
  • Cella E; Flavivirus Laboratory, Oswaldo Cruz Institute Oswaldo Cruz Foundation, Rio De Janeiro, Brazil.
  • Borsetti A; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
  • Ciotti M; Department of infectious diseases, National HIV/AIDS Research Center Istituto Superiore Di Sanità, Rome, Italy.
  • Ceccarelli G; Virology Unit, Laboratory of Clinical Microbiology and Virology, Polyclinic Tor Vergata Foundation, Rome, Italy.
  • D'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Pezzuto A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Tambone V; Cardiovascular-Respiratory Science Department, Sant' Andrea Hospital-Sapienza University, Rome, Italy.
  • Campanozzi L; Institute of Philosophy of Scientific and Technological Practice, Campus Bio-Medico University, Rome, Italy.
  • Magheri M; Institute of Philosophy of Scientific and Technological Practice, Campus Bio-Medico University, Rome, Italy.
  • Unali F; Communication Division, University Campus Bio-Medico of Rome, Rome, Italy.
  • Bianchi M; Communication Division, University Campus Bio-Medico of Rome, Rome, Italy.
  • Benedetti F; Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome "La Sapienza", Rome, Italy.
  • Pascarella S; Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, USA.
  • Angeletti S; Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome "La Sapienza", Rome, Italy.
  • Ciccozzi M; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
Expert Rev Mol Diagn ; 21(6): 547-562, 2021 06.
Article in English | MEDLINE | ID: covidwho-1182936
ABSTRACT

Introduction:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease, and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert opinion Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Nucleic Acid Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 14737159.2021.1917998

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Nucleic Acid Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 14737159.2021.1917998