Fecal Microbiota Transplantation for Ulcerative Colitis: An Evolving Therapy.
Crohns Colitis 360
; 2(4): otaa067, 2020 Oct.
Article
in English
| MEDLINE | ID: covidwho-1183000
ABSTRACT
Background:
Fecal microbiota transplantation (FMT) is currently an approved treatment for recurrent and refractory Clostridioides difficile infection. However, its use in ulcerative colitis is at an early stage and significant gaps remain in our understanding of the mechanisms and logistics of its practical application. Methods andresults:
This article aims to look into specific issues which remain unsettled for use of FMT in ulcerative colitis including donor and recipient selection, route of administration, and duration of therapy. We also discuss optimal ways to assess response to FMT and the current state of FMT regulations. In addition, we postulate the impact of diet on the microbiome profile of the donor and recipient. We also suggest a change in the nomenclature from FMT to fecal microbiome transfer.Conclusion:
FMT is an evolving therapy. There are several considerations for its use in UC but its use and role should be directed by further clinical trials.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Language:
English
Journal:
Crohns Colitis 360
Year:
2020
Document Type:
Article
Affiliation country:
Crocol
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