Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1.
Genome
; 64(4): 386-399, 2021 Apr.
Article
in English
| MEDLINE | ID: covidwho-1183386
ABSTRACT
The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney, and heart and detectable in a variety of tissues and cell types. Herein we review the chemical and mechanical signal transduction pathways regulating the expression of the ACE2 gene and the epigenetic/chromatin features of the expressed gene.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptors, Virus
/
Epigenesis, Genetic
/
Angiotensin-Converting Enzyme 2
Limits:
Humans
Language:
English
Journal:
Genome
Journal subject:
Genetics
Year:
2021
Document Type:
Article
Affiliation country:
Gen-2020-0124
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