Hyposmia Is Associated with Reduced Cognitive Function in COVID-19: First Preliminary Results.
Dement Geriatr Cogn Disord
; 50(1): 68-73, 2021.
Article
in English
| MEDLINE | ID: covidwho-1183423
ABSTRACT
BACKGROUND:
Hyposmia is frequently reported as an initial symptom in coronavirus disease 2019 (COVID-19).OBJECTIVE:
As hyposmia accompanies cognitive impairment in several neurological disorders, we aimed to study whether hyposmia represents a clinical biomarker for both neurological involvement and cognitive impairment in mild CO-VID-19. We aimed to study whether olfactory dysfunction (OD) represents a clinical biomarker for both neurological involvement and cognitive impairment in mild COVID-19.METHODS:
Formal olfactory testing using the Sniffin'Sticks® Screening test, neuropsychological assessment using the Montreal Cognitive Assessment (MoCA), and detailed neurological examination were performed in 7 COVID-19 patients with mild disease course and no history of olfactory or cognitive impairment, and 7 controls matched for age, sex, and education. Controls were initially admitted to a dedicated COVID-19 screening ward but tested negative by real-time PCR.RESULTS:
The number of correctly identified odors was significantly lower in COVID-19 than in controls (6 ± 3, vs. 10 ± 1 p = 0.028, r = 0.58). Total MoCA score was significantly lower in COVID-19 patients than in controls (20 ± 5 vs. 26 ± 3, p = 0.042, r = 0.54). Cognitive performance indicated by MoCA was associated with number of correctly identified odors in COVID-19 patients and controls (COVID-19 p = 0.018, 95% CI = 9-19; controls p = 0.18, r = 0.63, 95% CI = 13-18.5 r = 0.64). DISCUSSION/CONCLUSION:
OD is associated with cognitive impairment in controls and mild COVID-19. OD may represent a potentially useful clinical biomarker for subtle and even subclinical neurological involvement in severe acute respiratory distress syndrome coronavirus-2 infection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cognition
/
Cognitive Dysfunction
/
Anosmia
/
COVID-19
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Dement Geriatr Cogn Disord
Journal subject:
Geriatrics
/
Neurology
/
Psychiatry
Year:
2021
Document Type:
Article
Affiliation country:
000515575
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