Estrogen receptors and their roles in the immune and respiratory systems.
Anat Rec (Hoboken)
; 304(6): 1185-1193, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1184569
ABSTRACT
Estrogen is an important hormone for health in both genders. It is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, and neural functions. The main way that estrogen acts in the cells is through estrogen receptors (ERs). The presence of specific estrogen receptors is required for estrogen to have its characteristic ubiquitous action in almost all tissues. Estrogen receptor alpha (ERα) and estrogen receptor beta (ERß) are the major isoforms of estrogen that are highly specific in humans and enable selective hormonal actions in different tissues. This article reviews some of the observed estrogen actions and effects in different tissues and cells through these specific receptors. This ubiquitous, almost ordinary hormone may reveal itself as a significant factor that helped us to better understand the complexity of the human immune system response against respiratory infections, including the COVID-19, and especially in the current state of this painful pandemic.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory System
/
Estrogen Receptor alpha
/
Estrogen Receptor beta
/
SARS-CoV-2
/
COVID-19
/
Immune System
Limits:
Animals
/
Humans
Language:
English
Journal:
Anat Rec (Hoboken)
Journal subject:
Anatomy
Year:
2021
Document Type:
Article
Affiliation country:
Ar.24612
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