Pre-existing atrial fibrillation is associated with increased mortality in COVID-19 Patients.
J Interv Card Electrophysiol
; 62(2): 231-238, 2021 Nov.
Article
in English
| MEDLINE | ID: covidwho-1184690
ABSTRACT
PURPOSE:
The impacts of pre-existing atrial fibrillation (AF) on COVID-19-associated outcomes are unclear. We conducted a systematic review and meta-analysis to investigate the pooled prevalence of pre-existing AF and its short-term mortality risk in COVID-19 patients.METHODS:
Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE and Scopus to locate all the articles published up to January 31, 2021, reporting data on pre-existing AF among COVID-19 survivors and non-survivors. The pooled prevalence of pre-existing AF was calculated using a random effects model and presenting the related 95% confidence interval (CI), while the mortality risk was estimated using the Mantel-Haenszel random effects models with odds ratio (OR) and related 95% CI. Statistical heterogeneity was measured using the Higgins I2 statistic.RESULTS:
Twelve studies, enrolling 15.562 COVID-19 patients (mean age 71.6 years), met the inclusion criteria and were included in the final analysis. The pooled prevalence of pre-existing AF was 11.0% of cases (95% CI 7.8-15.2%, p < 0.0001) with high heterogeneity (I2 = 95.2%). Pre-existing AF was associated with higher risk of short-term death (OR 2.22, 95% CI 1.47-3.36, p < 0.0001), with high heterogeneity (I2 = 79.1%).CONCLUSION:
Pre-existing AF is present in about 11% of COVID-19 cases but results associated with an increased risk of short-term mortality.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Atrial Fibrillation
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Aged
/
Humans
Language:
English
Journal:
J Interv Card Electrophysiol
Journal subject:
Cardiology
Year:
2021
Document Type:
Article
Affiliation country:
S10840-021-00992-2
Similar
MEDLINE
...
LILACS
LIS