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Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review.
Saed Aldien, Arwa; Ganesan, Gowrii S; Wahbeh, Farah; Al-Nassr, Noor; Altarawneh, Heba; Al Theyab, Lolwa; Saed Aldien, Summia; Tomerak, Sara; Naveed, Hiba; Elshazly, Mohamed B; Zakaria, Dalia.
  • Saed Aldien A; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Ganesan GS; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Wahbeh F; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Al-Nassr N; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Altarawneh H; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Al Theyab L; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Saed Aldien S; McGill University, Faculty of Agricultural and Environmental Sciences.
  • Tomerak S; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Naveed H; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Elshazly MB; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar.
  • Zakaria D; Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Al, Luqta St. Ar-Rayyan, P.O. Box 24144, Doha, Qatar. Electronic address: dez2003@qatar-med.cornell.edu.
Cardiovasc Revasc Med ; 35: 169-178, 2022 02.
Article in English | MEDLINE | ID: covidwho-1184864
ABSTRACT
Coronavirus disease 2019(COVID-19) is an ongoing global pandemic with a daily increasing number of affected individuals and a relatively high mortality rate. COVID-19 patients that develop cardiac injury are at increased risk of a worse clinical course with higher rates of mortality. Increasing amounts of evidence suggest that a system-wide inflammatory response and a cytokine storm mediated type syndrome plays a crucial role in disease progression. This systematic review investigates the possible role of hyperinflammation in inducing cardiac injury as one of the severe complications of COVID-19. A systematic literature search was performed using PubMed, Embase and Scopus databases to identify relevant clinical studies that investigated cardiovascular injury manifestations and reported inflammatory and cardiac biomarkers in COVID-19 patients. Only 29 studies met our inclusion criteria and the majority of these studies demonstrated significantly elevated inflammatory and cardiac blood markers. It was evident that underlying cardiovascular diseases may increase the risk of developing cardiac injury. However, many COVID-19 patients included in this review, developed different types of cardiac injury without having any underlying cardiovascular diseases. Furthermore, many of these patients were either children or adolescents. Therefore, age and comorbidities may not always be the two main risk factors that dictate the severity and outcome of COVID-19. Further investigations are required to understand the underlying mechanisms of pathogenicity as an urgent requirement to develop the appropriate treatment and prevention strategies. These strategies may specifically target hyperinflammation as a suspected driving factor for some of the severe complications of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Adolescent / Child / Humans Language: English Journal: Cardiovasc Revasc Med Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: J.carrev.2021.04.007

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Adolescent / Child / Humans Language: English Journal: Cardiovasc Revasc Med Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: J.carrev.2021.04.007