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Estimating asymptomatic SARS-CoV-2 infections in a geographic area of low disease incidence.
Caturano, Valeria; Manti, Barbara; Carbone, Fortunata; Lasorsa, Vito Alessandro; Colicchio, Roberta; Capasso, Mario; Leonardi, Antonio; Matarese, Giuseppe; Russo, Tommaso; Salvatore, Paola.
  • Caturano V; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
  • Manti B; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
  • Carbone F; Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche (IEOS-CNR), Naples, Italy.
  • Lasorsa VA; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
  • Colicchio R; CEINGE Biotecnologie Avanzate s.c.ar.l., Naples, Italy.
  • Capasso M; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
  • Leonardi A; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
  • Matarese G; CEINGE Biotecnologie Avanzate s.c.ar.l., Naples, Italy.
  • Russo T; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
  • Salvatore P; Department of Molecular Medicine and Medical Biotechnology, University of Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
BMC Infect Dis ; 21(1): 350, 2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1186555
Semantic information from SemMedBD (by NLM)
1. Today TREATS Disease
Subject
Today
Predicate
TREATS
Object
Disease
2. Blood specimen PART_OF Serum
Subject
Blood specimen
Predicate
PART_OF
Object
Serum
3. Healthy Volunteers LOCATION_OF Blood specimen
Subject
Healthy Volunteers
Predicate
LOCATION_OF
Object
Blood specimen
4. SARS-CoV-2 IgG PART_OF Persons
Subject
SARS-CoV-2 IgG
Predicate
PART_OF
Object
Persons
5. Today TREATS Disease
Subject
Today
Predicate
TREATS
Object
Disease
6. Blood specimen PART_OF Serum
Subject
Blood specimen
Predicate
PART_OF
Object
Serum
7. Healthy Volunteers LOCATION_OF Blood specimen
Subject
Healthy Volunteers
Predicate
LOCATION_OF
Object
Blood specimen
8. SARS-CoV-2 IgG PART_OF Persons
Subject
SARS-CoV-2 IgG
Predicate
PART_OF
Object
Persons
ABSTRACT

BACKGROUND:

The SARS-CoV-2 infection has emerged as a rapidly spreading infection. Today it is relatively easy to isolate Covid-19 symptomatic cases, while remains problematic to control the disease spread by infected but symptom-free individuals. The control of this possible path of contagion requires drastic measures of social distancing, which imply the suspension of most activities and generate economic and social issues. This study is aimed at estimating the percentage of asymptomatic SARS-CoV-2 infection in a geographic area with relatively low incidence of Covid-19.

METHODS:

Blood serum samples from 388 healthy volunteers were analyzed for the presence of anti-SARS-CoV-2 IgG by using an ELISA assay based on recombinant viral nucleocapsid protein.

RESULTS:

We found that 7 out of 388 healthy volunteers, who declared no symptoms of Covid-19, like fever, cough, fatigue etc., in the preceding 5 months, have bona fide serum anti-SARS-CoV-2 IgG, that is 1.8% of the asymptomatic population (95% confidence interval 0.69-2.91%).

CONCLUSIONS:

The estimated range of asymptomatic individuals with anti-SARS-CoV-2 IgG should be between 26,565 and 112, 350. In the same geographic area, there are 4665 symptomatic diagnosed cases.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / COVID-19 / Antibodies, Viral Type of study: Incidence study / Prognostic study / Risk factors Limits: Adult / Aged / Humans / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06054-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / COVID-19 / Antibodies, Viral Type of study: Incidence study / Prognostic study / Risk factors Limits: Adult / Aged / Humans / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06054-2