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Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
Anand, Shuchi; Montez-Rath, Maria E; Han, Jialin; Garcia, Pablo; Bozeman, Julie; Kerschmann, Russell; Beyer, Paul; Parsonnet, Julie; Chertow, Glenn M.
  • Anand S; Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America.
  • Montez-Rath ME; Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America.
  • Han J; Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America.
  • Garcia P; Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America.
  • Bozeman J; Ascend Clinical Laboratory, Redwood City, California, United States of America.
  • Kerschmann R; Ascend Clinical Laboratory, Redwood City, California, United States of America.
  • Beyer P; Ascend Clinical Laboratory, Redwood City, California, United States of America.
  • Parsonnet J; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America.
  • Chertow GM; Department of Epidemiology and Population Health, Stanford University School of Medicine, Palo Alto, California, United States of America.
PLoS One ; 16(4): e0249466, 2021.
Article in English | MEDLINE | ID: covidwho-1186603
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
2. COVID-19 CAUSES Cessation of life
Subject
COVID-19
Predicate
CAUSES
Object
Cessation of life
3. Dialysis procedure ADMINISTERED_TO Patients
Subject
Dialysis procedure
Predicate
ADMINISTERED_TO
Object
Patients
4. GJA1 gene|GJA1 COEXISTS_WITH Hemoglobin
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
Hemoglobin
5. GJA1 gene|GJA1 COEXISTS_WITH parathyroid hormone
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
parathyroid hormone
6. GJA1 gene|GJA1 COEXISTS_WITH Phosphates
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
Phosphates
7. GJA1 gene|GJA1 COEXISTS_WITH potassium
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
potassium
8. GJA1 gene|GJA1 COEXISTS_WITH sodium
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
sodium
9. Poor Health PROCESS_OF Patients
Subject
Poor Health
Predicate
PROCESS_OF
Object
Patients
10. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
Patients
11. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
12. COVID-19 CAUSES Cessation of life
Subject
COVID-19
Predicate
CAUSES
Object
Cessation of life
13. Dialysis procedure ADMINISTERED_TO Patients
Subject
Dialysis procedure
Predicate
ADMINISTERED_TO
Object
Patients
14. GJA1 gene|GJA1 COEXISTS_WITH Hemoglobin
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
Hemoglobin
15. GJA1 gene|GJA1 COEXISTS_WITH parathyroid hormone
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
parathyroid hormone
16. GJA1 gene|GJA1 COEXISTS_WITH Phosphates
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
Phosphates
17. GJA1 gene|GJA1 COEXISTS_WITH potassium
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
potassium
18. GJA1 gene|GJA1 COEXISTS_WITH sodium
Subject
GJA1 gene|GJA1
Predicate
COEXISTS_WITH
Object
sodium
19. Poor Health PROCESS_OF Patients
Subject
Poor Health
Predicate
PROCESS_OF
Object
Patients
20. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Patients on dialysis are at high risk for death due to COVID-19, yet a significant proportion do survive as evidenced by presence of SARS-CoV-2 antibodies in 8% of patients in the U.S. in July 2020. It is unclear whether patients with seropositivity represent the subgroup with robust health status, who would be more likely to mount a durable antibody response. Using data from a July 2020 sample of 28,503 patients receiving dialysis, we evaluated the cross-sectional association of SARS-CoV-2 seropositivity with laboratory surrogates of patient health. In separate logistic regression models, we assessed the association of SARS-CoV-2 seropositivity with seven laboratory-based covariates (albumin, creatinine, hemoglobin, sodium, potassium, phosphate, and parathyroid hormone), across the entire range of the laboratory and in comparison to a referent value. Models accounted for age, sex, region, race and ethnicity, and county-level COVID-19 deaths per 100,000. Odds of seropositivity for albumin 3 and 3.5 g/dL were 2.1 (95% CI 1.9-2.3) and 1.3 (1.2-1.4) respectively, compared with 4 g/dL. Odds of seropositivity for serum creatinine 5 and 8 mg/dL were 1.8 (1.6-2.0) and 1.3 (1.2-1.4) respectively, compared with 12.5 mg/dL. Lower values of hemoglobin, sodium, potassium, phosphate, and parathyroid hormone were associated with higher odds of seropositivity. Laboratory values associated with poorer health status and higher risk for mortality were also associated with higher likelihood of SARS-CoV-2 antibodies in patients receiving dialysis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Renal Dialysis / SARS-CoV-2 / COVID-19 Subject: Renal Dialysis / SARS-CoV-2 / COVID-19 Type of study: Etiology study / Patient-preference / Prevalence study / Prognostic study / Risk factors Language: English Journal: PLoS One Clinical aspect: Diagnosis / Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Renal Dialysis / SARS-CoV-2 / COVID-19 Subject: Renal Dialysis / SARS-CoV-2 / COVID-19 Type of study: Etiology study / Patient-preference / Prevalence study / Prognostic study / Risk factors Language: English Journal: PLoS One Clinical aspect: Diagnosis / Etiology Year: 2021
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