Your browser doesn't support javascript.
Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology.
Aghayari Sheikh Neshin, Saeideh; Shahjouei, Shima; Koza, Eric; Friedenberg, Isabel; Khodadadi, Faezeh; Sabra, Mirna; Kobeissy, Firas; Ansari, Saeed; Tsivgoulis, Georgios; Li, Jiang; Abedi, Vida; Wolk, Donna M; Zand, Ramin.
  • Aghayari Sheikh Neshin S; Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran.
  • Shahjouei S; Neurology Department, Neuroscience Institute, Geisinger Health System, Danville, PA, United States.
  • Koza E; Geisinger Commonwealth School of Medicine, Scranton, PA, United States.
  • Friedenberg I; Department of Biology, Pennsylvania State University, State College, PA, United States.
  • Khodadadi F; PES University, Bengaluru, India.
  • Sabra M; Neurosciences Research Center (NRC), Lebanese University/Medical School, Beirut, Lebanon.
  • Kobeissy F; Program of Neurotrauma, Neuroproteomics and Biomarker Research (NNBR), University of Florida, Gainesville, FL, United States.
  • Ansari S; National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, United States.
  • Tsivgoulis G; Second Department of Neurology, School of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Li J; Department of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, United States.
  • Abedi V; Department of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, United States.
  • Wolk DM; Biocomplexity Institute, Virginia Tech, Blacksburg, VA, United States.
  • Zand R; Molecular and Microbial Diagnostics and Development, Diagnostic Medicine Institute, Laboratory Medicine, Geisinger Health System, Danville, PA, United States.
Front Cardiovasc Med ; 8: 649922, 2021.
Article in English | MEDLINE | ID: covidwho-1186796
ABSTRACT
Since the early days of the pandemic, there have been several reports of cerebrovascular complications during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Numerous studies proposed a role for SARS-CoV-2 in igniting stroke. In this review, we focused on the pathoetiology of stroke among the infected patients. We pictured the results of the SARS-CoV-2 invasion to the central nervous system (CNS) via neuronal and hematogenous routes, in addition to viral infection in peripheral tissues with extensive crosstalk with the CNS. SARS-CoV-2 infection results in pro-inflammatory cytokine and chemokine release and activation of the immune system, COVID-19-associated coagulopathy, endotheliitis and vasculitis, hypoxia, imbalance in the renin-angiotensin system, and cardiovascular complications that all may lead to the incidence of stroke. Critically ill patients, those with pre-existing comorbidities and patients taking certain medications, such as drugs with elevated risk for arrhythmia or thrombophilia, are more susceptible to a stroke after SARS-CoV-2 infection. By providing a pictorial narrative review, we illustrated these associations in detail to broaden the scope of our understanding of stroke in SARS-CoV-2-infected patients. We also discussed the role of antiplatelets and anticoagulants for stroke prevention and the need for a personalized approach among patients with SARS-CoV-2 infection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews Language: English Journal: Front Cardiovasc Med Year: 2021 Document Type: Article Affiliation country: Fcvm.2021.649922

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews Language: English Journal: Front Cardiovasc Med Year: 2021 Document Type: Article Affiliation country: Fcvm.2021.649922