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Ex uno, plures-From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology.
Forte, Elvira; McLellan, Micheal A; Skelly, Daniel A; Rosenthal, Nadia A.
  • Forte E; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • McLellan MA; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Skelly DA; Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
  • Rosenthal NA; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Int J Mol Sci ; 22(4)2021 Feb 19.
Article in English | MEDLINE | ID: covidwho-1186964
ABSTRACT
Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular System / Single-Cell Analysis / Transcriptome Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22042071

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular System / Single-Cell Analysis / Transcriptome Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22042071