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The prognostic role of cardiac troponin in hospitalized COVID-19 patients.
Tanboga, Ibrahim Halil; Canpolat, Ugur; Özcan Çetin, Elif Hande; Kundi, Harun; Turan, Sema; Celik, Osman; Ata, Naim; Çay, Serkan; Özeke, Özcan; Kaymaz, Cihangir; Topaloglu, Serkan.
  • Tanboga IH; Nisantasi University, Hisar Intercontinental Hospital, Cardiology, Istanbul, Turkey. Electronic address: haliltanboga@yahoo.com.
  • Canpolat U; Hacettepe University, Medical School, Department of Cardiology, Ankara, Turkey.
  • Özcan Çetin EH; Ankara City Hospital, Department of Cardiology, Ankara, Turkey.
  • Kundi H; Ankara City Hospital, Department of Cardiology, Ankara, Turkey.
  • Turan S; Ankara City Hospital, Department of Intensive Care, Ankara, Turkey.
  • Celik O; Republic of Turkey Ministry of Health, Ankara, Turkey.
  • Ata N; Republic of Turkey Ministry of Health, Ankara, Turkey.
  • Çay S; University of Health Sciences, Ankara City Hospital, Department of Cardiology, Ankara, Turkey.
  • Özeke Ö; University of Health Sciences, Ankara City Hospital, Department of Cardiology, Ankara, Turkey.
  • Kaymaz C; University of Health Sciences, Kartal Kosuyolu Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
  • Topaloglu S; University of Health Sciences, Ankara City Hospital, Department of Cardiology, Ankara, Turkey.
Atherosclerosis ; 325: 83-88, 2021 05.
Article in English | MEDLINE | ID: covidwho-1188306
ABSTRACT
BACKGROUND AND

AIMS:

Myocardial injury defined by elevation of cardiac troponins (cTn) in the course of coronavirus disease 2019 (COVID-19) pandemic has been reported, though not fully characterized yet. Using the Turkish nationwide centralized COVID-19 database, we sought to determine whether cTn measured within 24 h of admission may help identify 30-day all-cause mortality in hospitalized patients.

METHODS:

This retrospective cohort study was conducted at all hospitals in Turkey between March 11, 2020, and June 22, 2020. All hospitalized COVID-19 patients (≥18 years) who had cTn measurements within 24 h of admission were included. The primary outcome was 30-day all-cause mortality.

RESULTS:

A total of 14,855 COVID-19 patients (median age 49 years and 54% male) from 81 provinces of Turkey were included. Of these, 2020 patients (13.6%) were transferred to intensive care unit, 1165 patients (7.8%) needed mechanical ventilation, and 882 patients (5.9%) died during hospitalization. The prevalence of cTn positivity was 6.9% (n = 1027) in the hospitalized patients. cTn positivity was 5% in those patients alive at 30-day, and 44% in those who died. In multivariable Cox proportional hazard regression model, age, lactate dehydrogenase, and cTn were the strongest predictors of 30-day mortality, irrespective of cTn definition as a continuous, ordinal variable, or dichotomic variables.

CONCLUSIONS:

A single measurement of cTn at admission in patients with COVID-19 is associated with 30-day all-cause mortality and may have an important prognostic role for optimizing risk stratification.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Troponin / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Atherosclerosis Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Troponin / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Atherosclerosis Year: 2021 Document Type: Article