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Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review.
Sheikh, Abu Baker; Chourasia, Prabal Kumar; Javed, Nismat; Chourasia, Mehul Kumar; Suriya, Sajid S; Upadhyay, Shubhra; Ijaz, Fatima; Pal, Suman; Moghimi, Narges; Shekhar, Rahul.
  • Sheikh AB; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America. Electronic address: absheikh@salud.unm.edu.
  • Chourasia PK; Department of Hospital Medicine, Mary Washington Hospital, Fredericksburg, VA, United States of America.
  • Javed N; Department of Internal Medicine, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
  • Chourasia MK; School of Medicine, Ninewells Hospital, University of Dundee, UK.
  • Suriya SS; Department of Neurology, University of New Mexico, Albuquerque, NM, United States of America.
  • Upadhyay S; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
  • Ijaz F; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
  • Pal S; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
  • Moghimi N; Department of Neurology, University of New Mexico, Albuquerque, NM, United States of America.
  • Shekhar R; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
J Neuroimmunol ; 355: 577577, 2021 06 15.
Article in English | MEDLINE | ID: covidwho-1188801
ABSTRACT

OBJECTIVE:

The systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.

METHODS:

After protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann-Whitney U test, were used. P < 0.05 was considered significant.

RESULTS:

We identified 64 relevant articles. The mean age of the patients was 56 ± 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05).

CONCLUSIONS:

GBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid / Variants Limits: Humans Language: English Journal: J Neuroimmunol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid / Variants Limits: Humans Language: English Journal: J Neuroimmunol Year: 2021 Document Type: Article