Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge.

E, Ekbom; R, Frithiof; Öi, Emilsson; Im, Larson; M, Lipcsey; S, Rubertsson; E, Wallin; C, Janson; M, Hultström; A, Malinovschi

E, Ekbom; R, Frithiof; Öi, Emilsson; Im, Larson; M, Lipcsey; S, Rubertsson; E, Wallin; C, Janson; M, Hultström; A, Malinovschi.

E E; Department of Medical Sciences, Respiratory-, Allergy- and Sleep Research, Uppsala University, Uppsala, Sweden. Electronic address: emil.ekbom@medsci.uu.se.
R F; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
Öi E; Department of Medical Sciences, Respiratory-, Allergy- and Sleep Research, Uppsala University, Uppsala, Sweden.
Im L; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
M L; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden; Hedenstierna Laboratory, CIRRUS, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
S R; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
E W; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
C J; Department of Medical Sciences, Respiratory-, Allergy- and Sleep Research, Uppsala University, Uppsala, Sweden.
M H; Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden; Department of Medical Cell Biology, Integrative Physiology, Uppsala University, Uppsala, Sweden.
A M; Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.

Respir Med ; 182: 106394, 2021 06.

Article in English | MEDLINE | ID: covidwho-1188980

ABSTRACT

ABSTRACT

There is limited knowledge about the long-term effects on pulmonary function of COVID-19 in patients that required intensive care treatment. Spirometry and diffusing capacity for carbon monoxide (DLCO) were measured in 60 subjects at 3-6 months post discharge. Impaired lung function was found in 52% of the subjects, with reduced DLCO as the main finding. The risk increased with age above 60 years, need for mechanical ventilation and longer ICU stay as well as lower levels of C-reactive protein at admission. This suggests the need of follow-up with pulmonary function testing in intensive-care treated patients.

Subject(s)

COVID-19/physiopathology; Carbon Monoxide/metabolism; Critical Illness; Lung/physiopathology; Patient Discharge; Pulmonary Diffusing Capacity/physiology; COVID-19/metabolism; Humans; SARS-CoV-2; Spirometry; Time Factors

Keywords

ARDS; COVID-19; Diffusion capacity; Follow up; ICU treatment; Lung function

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Discharge / Carbon Monoxide / Pulmonary Diffusing Capacity / Critical Illness / COVID-19 / Lung Type of study: Cohort study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Respir Med Year: 2021 Document Type: Article

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