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Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.
Nanoscale ; 13(13): 6410-6416, 2021 Apr 07.
Article in English | MEDLINE | ID: covidwho-1189295
ABSTRACT
The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / SARS-CoV-2 / COVID-19 Drug Treatment / Niclosamide Topics: Vaccines Limits: Humans Language: English Journal: Nanoscale Year: 2021 Document Type: Article Affiliation country: D1nr00309g

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / SARS-CoV-2 / COVID-19 Drug Treatment / Niclosamide Topics: Vaccines Limits: Humans Language: English Journal: Nanoscale Year: 2021 Document Type: Article Affiliation country: D1nr00309g