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SARS-CoV-2 infection in schools in a northern French city: a retrospective serological cohort study in an area of high transmission, France, January to April 2020.
Fontanet, Arnaud; Tondeur, Laura; Grant, Rebecca; Temmam, Sarah; Madec, Yoann; Bigot, Thomas; Grzelak, Ludivine; Cailleau, Isabelle; Besombes, Camille; Ungeheuer, Marie-Noëlle; Renaudat, Charlotte; Perlaza, Blanca Liliana; Arowas, Laurence; Jolly, Nathalie; Pellerin, Sandrine Fernandes; Kuhmel, Lucie; Staropoli, Isabelle; Huon, Christèle; Chen, Kuang-Yu; Crescenzo-Chaigne, Bernadette; Munier, Sandie; Charneau, Pierre; Demeret, Caroline; Bruel, Timothée; Eloit, Marc; Schwartz, Olivier; Hoen, Bruno.
  • Fontanet A; PACRI Unit, Conservatoire National des Arts et Métiers, Paris, France.
  • Tondeur L; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Grant R; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Temmam S; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Madec Y; Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.
  • Bigot T; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Grzelak L; Bioinformatic and Biostatistic Hub - Computational Biology Department, Institut Pasteur, Paris, France.
  • Cailleau I; Université de Paris, Sorbonne Paris Cité, Paris, France.
  • Besombes C; UMR 3569, Centre National de la Recherche Scientifique, Paris, France.
  • Ungeheuer MN; Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.
  • Renaudat C; Direction de la recherche médicale, Institut Pasteur, Paris, France.
  • Perlaza BL; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
  • Arowas L; ICAReB platform (Clinical Investigation & Access to Research Bioresources) of the Center for Translational Science, Institut Pasteur, Paris, France.
  • Jolly N; ICAReB platform (Clinical Investigation & Access to Research Bioresources) of the Center for Translational Science, Institut Pasteur, Paris, France.
  • Pellerin SF; ICAReB platform (Clinical Investigation & Access to Research Bioresources) of the Center for Translational Science, Institut Pasteur, Paris, France.
  • Kuhmel L; ICAReB platform (Clinical Investigation & Access to Research Bioresources) of the Center for Translational Science, Institut Pasteur, Paris, France.
  • Staropoli I; Center for Translational Sciences, Institut Pasteur, Paris, France.
  • Huon C; Center for Translational Sciences, Institut Pasteur, Paris, France.
  • Chen KY; Medical Center of the Institut Pasteur, Institut Pasteur, Paris, France.
  • Crescenzo-Chaigne B; Vaccine Research Institute, Creteil, France.
  • Munier S; UMR 3569, Centre National de la Recherche Scientifique, Paris, France.
  • Charneau P; Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.
  • Demeret C; Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.
  • Bruel T; RNA Biology of Influenza Virus, Department of Virology, Institut Pasteur, Paris, France.
  • Eloit M; Molecular Genetics of RNA Viruses, Institut Pasteur, Paris, France.
  • Schwartz O; Université de Paris, Sorbonne Paris Cité, Paris, France.
  • Hoen B; UMR 3569, Centre National de la Recherche Scientifique, Paris, France.
Euro Surveill ; 26(15)2021 04.
Article in English | MEDLINE | ID: covidwho-1190261
Semantic information from SemMedBD (by NLM)
1. Pupil LOCATION_OF Hydranencephaly with Renal Aplasia-Dysplasia
Subject
Pupil
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LOCATION_OF
Object
Hydranencephaly with Renal Aplasia-Dysplasia
2. Circulatory Process PROCESS_OF parent
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Circulatory Process
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PROCESS_OF
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parent
3. Circulatory Process PROCESS_OF Relative (related person)
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Circulatory Process
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PROCESS_OF
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Relative (related person)
4. 2019 novel coronavirus PROCESS_OF Child
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2019 novel coronavirus
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Child
5. Pupil LOCATION_OF Hydranencephaly with Renal Aplasia-Dysplasia
Subject
Pupil
Predicate
LOCATION_OF
Object
Hydranencephaly with Renal Aplasia-Dysplasia
6. Circulatory Process PROCESS_OF parent
Subject
Circulatory Process
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PROCESS_OF
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parent
7. Circulatory Process PROCESS_OF Relative (related person)
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Circulatory Process
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PROCESS_OF
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Relative (related person)
8. 2019 novel coronavirus PROCESS_OF Child
Subject
2019 novel coronavirus
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PROCESS_OF
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Child
ABSTRACT
BackgroundChildren's role in SARS-CoV-2 epidemiology remains unclear. We investigated an initially unnoticed SARS-CoV-2 outbreak linked to schools in northern France, beginning as early as mid-January 2020.AimsThis retrospective observational study documents the extent of SARS-CoV-2 transmission, linked to an affected high school (n = 664 participants) and primary schools (n = 1,340 study participants), in the context of unsuspected SARS-CoV-2 circulation and limited control measures.MethodsBetween 30 March and 30 April 2020, all school staff, as well as pupils and their parents and relatives were invited for SARS-CoV-2 antibody testing and to complete a questionnaire covering symptom history since 13 January 2020.ResultsIn the high school, infection attack rates were 38.1% (91/239), 43.4% (23/53), and 59.3% (16/27), in pupils, teachers, and non-teaching staff respectively vs 10.1% (23/228) and 12.0% (14/117) in the pupils' parents and relatives (p < 0.001). Among the six primary schools, three children attending separate schools at the outbreak start, while symptomatic, might have introduced SARS-CoV-2 there, but symptomatic secondary cases related to them could not be definitely identified. In the primary schools overall, antibody prevalence in pupils sharing classes with symptomatic cases was higher than in pupils from other classes 15/65 (23.1%) vs 30/445 (6.7%) (p < 0.001). Among 46 SARS-CoV-2 seropositive pupils < 12 years old, 20 were asymptomatic. Whether past HKU1 and OC43 seasonal coronavirus infection protected against SARS-CoV-2 infection in 6-11 year olds could not be inferred.ConclusionsViral circulation can occur in high and primary schools so keeping them open requires consideration of appropriate control measures and enhanced surveillance.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Child / Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.15.2001695

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Child / Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.15.2001695