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Age-Related Dynamics of Lung-Resident Memory CD8+ T Cells in the Age of COVID-19.
Goplen, Nick P; Cheon, In Su; Sun, Jie.
  • Goplen NP; Division of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
  • Cheon IS; Division of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
  • Sun J; Division of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
Front Immunol ; 12: 636118, 2021.
Article in English | MEDLINE | ID: covidwho-1190312
ABSTRACT
Following respiratory viral infections or local immunizations, lung resident-memory T cells (TRM) of the CD8 lineage provide protection against the same pathogen or related pathogens with cross-reactive T cell epitopes. Yet, it is now clear that, if homeostatic controls are lost following viral pneumonia, CD8 TRM cells can mediate pulmonary pathology. We recently showed that the aging process can result in loss of homeostatic controls on CD8 TRM cells in the respiratory tract. This may be germane to treatment modalities in both influenza and coronavirus disease 2019 (COVID-19) patients, particularly, the portion that present with symptoms linked to long-lasting lung dysfunction. Here, we review the developmental cues and functionalities of CD8 TRM cells in viral pneumonia models with a particular focus on their capacity to mediate heterogeneous responses of immunity and pathology depending on immune status.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Immunologic Memory / Lung Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.636118

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 / Immunologic Memory / Lung Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.636118