Progress in research in diagnosis of SARS-CoV-2 infection based on proteomics technique

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has swept the world in 2020, resulting in unprecedented pandemic of coronavirus disease 2019 (COVID-19). The number of infected persons and deaths increase every day at a frightening speed, threatening the health and life of people in the world and causing heavy burden to the global public health system. So far, nucleic acid detection is the main diagnostic method and gold standard for COVID-19. Meanwhile, other techniques and methods are also in developing for the diagnosis of SARS-CoV-2 infection. Proteomics technique is one of them. Proteomics technique has been widely used in the research of disease-related mechanism, development of diagnostic methods and pathogen identification. Up to now, there are mainly two applications of proteomics in the diagnosis of SARS-CoV-2 infection. First, proteomics based on virus particles has great potential in early diagnosis. Second, proteomics based on body fluids can be used not only for early diagnosis, but also for good monitoring the progress of infection, predicting the trend of disease, and evaluating the prognoses. In this paper, the research and application of proteomics technique in the diagnosis of SARS-CoV-2 infection in the world are summarized and prospected.