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Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function.
Allwood, B W; Stolbrink, M; Baines, N; Louw, E; Wademan, D T; Lupton-Smith, A; Nel, S; Maree, D; Mpagama, S; Osman, M; Marx, F M; Hoddinott, G; Lesosky, M; Rylance, J; Mortimer, K.
  • Allwood BW; Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa.
  • Stolbrink M; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Baines N; Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa.
  • Louw E; Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa.
  • Wademan DT; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Lupton-Smith A; Department of Science and Innovation-National Research Foundation South African Centre for Excellence in Epidemiological Modelling and Analysis (SACEMA), Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.
  • Nel S; Department of Physical Medicine and Rehabilitation, School of Medicine, Faculty of Health Sciences, University of Namibia, Windhoek, Namibia.
  • Maree D; Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa.
  • Mpagama S; Kibong´oto Infectious Diseases Hospital, Kilimanjaro, Tanzania.
  • Osman M; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Marx FM; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, Department of Science and Innovation-National Research Foundation South African Centre for Excellence in Epidemiological Modelling and Analys
  • Hoddinott G; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Lesosky M; Division of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, South Africa, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Rylance J; Lung Health Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Mortimer K; Liverpool School of Tropical Medicine, Liverpool, UK.
Int J Tuberc Lung Dis ; 25(4): 262-270, 2021 04 01.
Article in English | MEDLINE | ID: covidwho-1190586
ABSTRACT

BACKGROUND:

Persistent respiratory symptoms and lung function deficits are common after patients with TB. We aimed to define the burden of post-TB lung disease (PTLD) and assess associations between symptoms and impairment in two high TB incidence communities.

METHODS:

This was a cross-sectional survey of adults in Cape Town, South Africa who completed TB treatment 1-5 years previously. Questionnaires, spirometry and 6-minute walking distance (6MWD) were used to assess relationships between outcome measures and associated factors.

RESULTS:

Of the 145 participants recruited (mean age 42 years, range 18-75; 55 [38%] women), 55 (38%) had airflow obstruction and 84 (58%) had low forced vital capacity (FVC); the mean 6MWD was 463 m (range 240-723). Respiratory symptoms were common chronic cough (n = 27, 19%), wheeze (n = 61, 42%) and dyspnoea (modified MRC dyspnoea score 3 or 4 n = 36, 25%). There was poor correlation between FVC or obstruction and 6MWD. Only low body mass index showed consistent association with outcomes on multivariable analyses. Only 19 (13%) participants had a diagnosis of respiratory disease, and 16 (11%) currently received inhalers.

CONCLUSION:

There was substantial burden of symptoms and physiological impairment in this "cured" population, but poor correlation between objective outcome measures, highlighting deficits in our understanding of PTLD.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Lung Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans Country/Region as subject: Africa Language: English Journal: Int J Tuberc Lung Dis Year: 2021 Document Type: Article Affiliation country: Ijtld.20.0906

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Lung Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans Country/Region as subject: Africa Language: English Journal: Int J Tuberc Lung Dis Year: 2021 Document Type: Article Affiliation country: Ijtld.20.0906