Potential drug interactions of traditional Chinese medicine injections in treatment of COVID-19 and western medicine commonly used for cardiovascular diseases base on cytochrome P450 enzyme

ABSTRACT

Traditional Chinese medicine injection, a scientific and technological innovation of traditional Chinese medicine, plays a unique advantage in the treatment of severe patients with new corona virus pneumonia (COVID-19). Epidemiological studies have found that a considerable number of severe patients with COVID-19 have cardiovascular diseases such as hypertension and coronary heart disease, which need to be controlled during anti-virus treatment, resulting in the increasingly prevalence of drug interactions between traditional Chinese medicine injections and chemical medicines. By consulting the literatures, we summarized the effects of eight commonly used traditional Chinese medicine injections in Diagnosis and Treatment Protocol for COVID-19 (Trial Version 8) on cytochrome P450 enzyme (CYP450), and analyzed their interaction with commonly used chemical medicines for cardiovascular diseases, so as to provide references for clinical rational administration and promote the advantages of traditional Chinese medicine against the epidemic disease. © 2021, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved.