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Modeling Immunity In Vitro: Slices, Chips, and Engineered Tissues.
Hammel, Jennifer H; Cook, Sophie R; Belanger, Maura C; Munson, Jennifer M; Pompano, Rebecca R.
  • Hammel JH; Fralin Biomedical Research Institute and Department of Biomedical Engineering and Mechanics, Virginia Tech, Roanoke, Virginia 24016, USA; email: jm4kt@vt.edu.
  • Cook SR; Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
  • Belanger MC; Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
  • Munson JM; Fralin Biomedical Research Institute and Department of Biomedical Engineering and Mechanics, Virginia Tech, Roanoke, Virginia 24016, USA; email: jm4kt@vt.edu.
  • Pompano RR; Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
Annu Rev Biomed Eng ; 23: 461-491, 2021 07 13.
Article in English | MEDLINE | ID: covidwho-1191179
ABSTRACT
Modeling immunity in vitro has the potential to be a powerful tool for investigating fundamental biological questions, informing therapeutics and vaccines, and providing new insight into disease progression. There are two major elements to immunity that are necessary to model primary immune tissues and peripheral tissues with immune components. Here, we systematically review progress made along three strategies to modeling immunity ex vivo cultures, which preserve native tissue structure; microfluidic devices, which constitute a versatile approach to providing physiologically relevant fluid flow and environmental control; and engineered tissues, which provide precise control of the 3D microenvironment and biophysical cues. While many models focus on disease modeling, more primary immune tissue models are necessary to advance the field. Moving forward, we anticipate that the expansion of patient-specific models may inform why immunity varies from patient to patient and allow for the rapid comprehension and treatment of emerging diseases, such as coronavirus disease 2019.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tissue Engineering / COVID-19 Type of study: Reviews Topics: Vaccines Limits: Animals / Humans Language: English Journal: Annu Rev Biomed Eng Journal subject: Biomedical Engineering Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tissue Engineering / COVID-19 Type of study: Reviews Topics: Vaccines Limits: Animals / Humans Language: English Journal: Annu Rev Biomed Eng Journal subject: Biomedical Engineering Year: 2021 Document Type: Article