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New Roles for Vitamin D Superagonists: From COVID to Cancer.
Easty, David J; Farr, Christine J; Hennessy, Bryan T.
  • Easty DJ; Department of Medical Oncology, Our Lady of Lourdes Hospital, Drogheda, Ireland.
  • Farr CJ; Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
  • Hennessy BT; Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Front Endocrinol (Lausanne) ; 12: 644298, 2021.
Article in English | MEDLINE | ID: covidwho-1191681
ABSTRACT
Vitamin D is a potent steroid hormone that induces widespread changes in gene expression and controls key biological pathways. Here we review pathophysiology of vitamin D with particular reference to COVID-19 and pancreatic cancer. Utility as a therapeutic agent is limited by hypercalcemic effects and attempts to circumvent this problem have used vitamin D superagonists, with increased efficacy and reduced calcemic effect. A further caveat is that vitamin D mediates multiple diverse effects. Some of these (anti-fibrosis) are likely beneficial in patients with COVID-19 and pancreatic cancer, whereas others (reduced immunity), may be beneficial through attenuation of the cytokine storm in patients with advanced COVID-19, but detrimental in pancreatic cancer. Vitamin D superagonists represent an untapped resource for development of effective therapeutic agents. However, to be successful this approach will require agonists with high cell-tissue specificity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancreatic Neoplasms / Vitamin D / Vitamins / Carcinoma, Pancreatic Ductal / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.644298

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancreatic Neoplasms / Vitamin D / Vitamins / Carcinoma, Pancreatic Ductal / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.644298