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Central nervous system vasculopathy associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a novel case report from Iran.
Hosseini, Mohammad Javad; Halaji, Mehrdad; Nejad, Javad Hosseini; Ranjbar, Reza.
  • Hosseini MJ; Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Halaji M; Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Nejad JH; Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Ranjbar R; Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. ranjbarre@gmail.com.
J Neurovirol ; 27(3): 507-509, 2021 06.
Article in English | MEDLINE | ID: covidwho-1193170
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus COEXISTS_WITH Central nervous system vascular Disease
Subject
2019 novel coronavirus
Predicate
COEXISTS_WITH
Object
Central nervous system vascular Disease
2. Brain LOCATION_OF Magnetic Resonance Imaging
Subject
Brain
Predicate
LOCATION_OF
Object
Magnetic Resonance Imaging
3. Magnetic Resonance Imaging DIAGNOSES Cerebrovascular Disorders
Subject
Magnetic Resonance Imaging
Predicate
DIAGNOSES
Object
Cerebrovascular Disorders
4. Real-Time Polymerase Chain Reaction METHOD_OF Molecular Diagnostic Techniques
Subject
Real-Time Polymerase Chain Reaction
Predicate
METHOD_OF
Object
Molecular Diagnostic Techniques
5. Supportive care ADMINISTERED_TO Patients
Subject
Supportive care
Predicate
ADMINISTERED_TO
Object
Patients
6. Influenza-like symptoms PROCESS_OF Male population group
Subject
Influenza-like symptoms
Predicate
PROCESS_OF
Object
Male population group
7. Worse PROCESS_OF Patients
Subject
Worse
Predicate
PROCESS_OF
Object
Patients
8. Virus INTERACTS_WITH COVID-19
Subject
Virus
Predicate
INTERACTS_WITH
Object
COVID-19
9. 2019 novel coronavirus COEXISTS_WITH Central nervous system vascular Disease
Subject
2019 novel coronavirus
Predicate
COEXISTS_WITH
Object
Central nervous system vascular Disease
10. Brain LOCATION_OF Magnetic Resonance Imaging
Subject
Brain
Predicate
LOCATION_OF
Object
Magnetic Resonance Imaging
11. Magnetic Resonance Imaging DIAGNOSES Cerebrovascular Disorders
Subject
Magnetic Resonance Imaging
Predicate
DIAGNOSES
Object
Cerebrovascular Disorders
12. Real-Time Polymerase Chain Reaction METHOD_OF Molecular Diagnostic Techniques
Subject
Real-Time Polymerase Chain Reaction
Predicate
METHOD_OF
Object
Molecular Diagnostic Techniques
13. Supportive care ADMINISTERED_TO Patients
Subject
Supportive care
Predicate
ADMINISTERED_TO
Object
Patients
14. Influenza-like symptoms PROCESS_OF Male population group
Subject
Influenza-like symptoms
Predicate
PROCESS_OF
Object
Male population group
15. Worse PROCESS_OF Patients
Subject
Worse
Predicate
PROCESS_OF
Object
Patients
16. Virus INTERACTS_WITH COVID-19
Subject
Virus
Predicate
INTERACTS_WITH
Object
COVID-19
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents respiratory symptoms as the most common clinical manifestations. Similar to some other viral infections, it can cause severe neurological damages. Here, we describe a 40-year-old man case who initially was admitted to a major hospital with presenting 7 days with weak flu-like symptoms (cough) and fever then presented neurology signs for 3 days. Physical examination and brain magnetic resonance imaging (MRI) showed cerebral vasculopathy. Molecular testing was performed on nasopharyngeal swab by real-time reverse transcription polymerase chain reaction (RT-PCR) which was positive for SARS-CoV-2. The patient received supportive cares and was treated with routine antiplatelet therapy. He was improved and discharged 10 days after admission with no symptoms. Our findings report a 40-year-old man with flu-like symptoms that indicate cerebral vasculopathy that was discharged with no symptoms. Therefore, physicians should be monitor patients with worsening or progressive central nervous system results. The pathobiology of this virus is still incompletely known; therefore, extensive studies are needed to reveal the effect of COVID-19 on the nervous system.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arteritis / Brain Diseases / COVID-19 Type of study: Risk factors Limits: Adult / Humans / Male Country/Region as subject: Asia Language: English Journal: J Neurovirol Journal subject: Neurology / Virology Year: 2021 Document Type: Article Affiliation country: S13365-021-00979-9

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arteritis / Brain Diseases / COVID-19 Type of study: Risk factors Limits: Adult / Humans / Male Country/Region as subject: Asia Language: English Journal: J Neurovirol Journal subject: Neurology / Virology Year: 2021 Document Type: Article Affiliation country: S13365-021-00979-9