Efficacy and safety of lopinavir-ritonavir in COVID-19: A systematic review of randomized controlled trials.
J Infect Public Health
; 14(6): 740-748, 2021 Jun.
Article
in English
| MEDLINE | ID: covidwho-1193397
ABSTRACT
BACKGROUND:
Lopinavir-ritonavir is a repurposed drug for coronavirus disease-2019 (COVID-19). In this study, a pooled effect of lopinavir-ritonavir on mortality, virological cure, radiological improvement and safety profile in COVID-19 patients has been evaluated.METHODS:
The databases were searched for comparative randomized controlled studies evaluating the efficacy and/or safety of lopinavir-ritonavir in COVID-19 patients. The mortality outcome was pooled as a risk difference (RD) with 95% CI. The virological cure, radiological improvement and adverse events were pooled as risk ratio (RR) with 95% CI. All outcomes were pooled using the Mantle-Hanzle method random effect model. The heterogeneity was assessed using the I2 test.RESULTS:
Out of 82 full text assessed, seven studies were included in the analysis. The included studies had five different controlinterventions:
supportive care (n=4), umifenovir (arbidol) (n=2), navaferon (recombinant anti-tumour and anti-virus protein) (n=1), lopinavir-ritonavir+novaferon (n=1) and lopinavir-ritonavir+interferon beta 1b+ribavirin (n=1). Lopinavir-ritonavir group did not show significant difference in mortality [RD 0.00 (95% CI -0.01, 0.02), I2=0], virological cure [RR 1.06 (95% CI 0.85, 1.31), I2=0%], radiological improvement [RR 0.81 (95% CI 0.62, 1.05)] and adverse events [RR 2.59 (95% CI 0.17, 38.90), I2=75%] than supportive care. Similarly, no difference was observed for any efficacy outcomes between lopinavir-ritonavir and other control interventions. We observed significantly high risk of adverse events with lopinavir-ritonavir as compared to umifenovir [RR 2.96 (95% CI 1.42-6.18); I2=0%].CONCLUSION:
There is no benefit of the addition of lopinavir-ritonavir to the standard care in COVID-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ritonavir
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
J Infect Public Health
Journal subject:
Communicable Diseases
/
Public Health
Year:
2021
Document Type:
Article
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