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Low Prevalence of Antibodies to SARS-CoV-2 and Undetectable Viral Load in Seropositive Blood Donors from South-Eastern Italy.
Di Stefano, Mariantonietta; Sarno, Michelina; Faleo, Giuseppina; Farhan Mohamed, Ahmed Mohamed; Lipsi, Maria Rosaria; De Nittis, Rosella; Bruno, Serena Rita; De Feo, Lucia; Granato, Tommaso; Corso, Gaetano; Arena, Fabio; Centra, Michele; Lo Caputo, Sergio; Margaglione, Maurizio; Santantonio, Teresa Antonia; Fiore, Jose Ramon.
  • Di Stefano M; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Foggia, Foggia, Italy.
  • Sarno M; Transfusion Medicine Center, AOU Policlinico Riuniti Foggia, Foggia, Italy.
  • Faleo G; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Foggia, Foggia, Italy.
  • Farhan Mohamed AM; Department of General Courses, College of Applied Studies and Community Service, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Lipsi MR; Microbiology and Virology Section, AOU Policlinico Riuniti, Foggia, Italy.
  • De Nittis R; Microbiology and Virology Section, AOU Policlinico Riuniti, Foggia, Italy.
  • Bruno SR; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Foggia, Foggia, Italy.
  • De Feo L; Transfusion Medicine Center, AOU Policlinico Riuniti Foggia, Foggia, Italy.
  • Granato T; Transfusion Medicine Center, AOU Policlinico Riuniti Foggia, Foggia, Italy.
  • Corso G; Department of Clinical and Experimental Medicine, Section of Clinical Biochemistry, University of Foggia, Foggia, Italy.
  • Arena F; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  • Centra M; Transfusion Medicine Center, AOU Policlinico Riuniti Foggia, Foggia, Italy.
  • Lo Caputo S; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Foggia, Foggia, Italy.
  • Margaglione M; Department of Clinical and Experimental Medicine, Section of Genetics, University of Foggia, Foggia, Italy.
  • Santantonio TA; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Foggia, Foggia, Italy.
  • Fiore JR; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Foggia, Foggia, Italy.
Acta Haematol ; 144(5): 580-584, 2021.
Article in English | MEDLINE | ID: covidwho-1194384
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus PROCESS_OF Blood donor
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Blood donor
2. Betacoronavirus CAUSES Pneumonia
Subject
Betacoronavirus
Predicate
CAUSES
Object
Pneumonia
3. Anti-Antibodies PART_OF 2019 novel coronavirus
Subject
Anti-Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
4. Virus PROCESS_OF Blood donor
Subject
Virus
Predicate
PROCESS_OF
Object
Blood donor
5. 2019 novel coronavirus PROCESS_OF Blood donor
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Blood donor
6. Betacoronavirus CAUSES Pneumonia
Subject
Betacoronavirus
Predicate
CAUSES
Object
Pneumonia
7. Anti-Antibodies PART_OF 2019 novel coronavirus
Subject
Anti-Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
8. Virus PROCESS_OF Blood donor
Subject
Virus
Predicate
PROCESS_OF
Object
Blood donor
ABSTRACT
Recently, a significant cluster of pneumonia caused by a novel betacoronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) was described initially in China and then spread throughout the world. Like other coronaviridae, the viral transmission occurs mainly through droplets. In addition, the virus has been detected in different clinical specimens, suggesting a potential transmission by other routes, including blood transfusion. However, the potential risk of transmission of SARS-CoV-2 via blood products is still unclear. The aim of our study was to investigate the prevalence of antibodies against SARS-CoV-2 among blood donors from South-Eastern Italy. Moreover, in the seropositive donors, we searched for the presence of the virus in nasopharyngeal swabs and in plasma samples. Overall, 1,797 blood donors from the Apulia region were tested for anti-SARS-CoV-2 antibodies, using a commercially available assay. Only 18/1,797 donors (1.0%) tested positive for anti-SARS-CoV-2 antibodies; in none of them SARS-CoV-2 viral RNA was detected in nasopharyngeal swabs and in plasma samples. Our results indicate that most of the blood donors in Apulia remained uninfected during this wave of the pandemic; further, none had detectable virus both in nasopharyngeal swabs and in blood samples. The risk to carry and transmit the virus by healthy and asymptomatic blood donors is probably very low.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prevalence study / Risk factors Language: English Journal: Acta Haematol Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prevalence study / Risk factors Language: English Journal: Acta Haematol Clinical aspect: Etiology Year: 2021
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