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COVID-19: a basic approach to understanding potential treatments.
Cedillo-Alvarez, Carla; Gallardo-Ortiz, Itzell A; López, Luis T; Montes, Sergio; Páez-Martínez, Nayeli.
  • Cedillo-Alvarez C; Research Section, Escuela Militar de Medicina, Secretaría de la Defensa Nacional, Mexico City.
  • Gallardo-Ortiz IA; Biomedical Research Unit, Iztacala Faculty of Higher Studies, Universidad Nacional Autónoma de México, State of Mexico.
  • López LT; Neurochemistry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City.
  • Montes S; Neurochemistry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City.
  • Páez-Martínez N; Post-degree and Research Section, Higher School of Medicine, Instituto Politécnico Nacional, Mexico City. Mexico.
Gac Med Mex ; 156(6): 570-575, 2020.
Article in English | MEDLINE | ID: covidwho-1194843
ABSTRACT
SARS-CoV-2 virus has been identified as the causative agent of the COVID-19 pandemic. Even when no standard treatment is available, antivirals such as remdesivir and other drugs such as chloroquine and ivermectin, which interfere with viral replication, have been assayed. Some strategies aimed at reducing immune mechanisms, such as the use of tocilizumab and natural antioxidants, have also been tested. The use of drugs related to the renin-angiotensin system has been controversial. Pathogenicity mechanisms, as well as controlled treatments, still have to be studied in detail in order to propose a viable therapeutic option that prevents the entry and replication of the virus or enhances the host immune system.El virus SARS-CoV-2 ha sido identificado como el agente patológico causante de la pandemia de COVID-19. Aun cuando no se cuenta con un tratamiento estándar, se han probado antivirales como remdesivir y otros fármacos como cloroquina e ivermectina, que interfieren con la replicación del virus. También se han intentado algunas estrategias encaminadas a disminuir los mecanismos inmunitarios, como el uso de tocilizumab y antioxidantes naturales. Los fármacos relacionados con el sistema renina-angiotensina han resultado controversiales. Aún se debe estudiar con detalle los mecanismos de patogenicidad, así como los tratamientos controlados para proponer alguna opción terapéutica viable que evite la entrada y replicación del virus o que aumente los sistemas inmunitarios del huésped.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment Type of study: Experimental Studies Limits: Animals / Humans Language: English Journal: Gac Med Mex Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment Type of study: Experimental Studies Limits: Animals / Humans Language: English Journal: Gac Med Mex Year: 2020 Document Type: Article