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Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.
Wei, H; Liang, G; Vera, R M.
  • Wei H; Department of Anaesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA. Huafeng.wei@pennmedicine.upenn.edu.
Eur Rev Med Pharmacol Sci ; 25(7): 3136-3144, 2021 04.
Article in English | MEDLINE | ID: covidwho-1194855
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. calcium ion ASSOCIATED_WITH Multiple Organ Failure
Subject
calcium ion
Predicate
ASSOCIATED_WITH
Object
Multiple Organ Failure
3. calcium ion ASSOCIATED_WITH Septicemia
Subject
calcium ion
Predicate
ASSOCIATED_WITH
Object
Septicemia
4. calcium ion ASSOCIATED_WITH Septic Shock
Subject
calcium ion
Predicate
ASSOCIATED_WITH
Object
Septic Shock
5. Septic Shock PROCESS_OF Patients
Subject
Septic Shock
Predicate
PROCESS_OF
Object
Patients
6. Ryanodine TREATS Multiple Organ Failure
Subject
Ryanodine
Predicate
TREATS
Object
Multiple Organ Failure
7. Ryanodine TREATS Systemic Inflammatory Response Syndrome
Subject
Ryanodine
Predicate
TREATS
Object
Systemic Inflammatory Response Syndrome
8. Inhibitor ASSOCIATED_WITH Septicemia
Subject
Inhibitor
Predicate
ASSOCIATED_WITH
Object
Septicemia
9. Inhibitor ASSOCIATED_WITH Septic Shock
Subject
Inhibitor
Predicate
ASSOCIATED_WITH
Object
Septic Shock
10. dantrolene TREATS Septicemia
Subject
dantrolene
Predicate
TREATS
Object
Septicemia
11. dantrolene TREATS Septic Shock
Subject
dantrolene
Predicate
TREATS
Object
Septic Shock
12. Cells LOCATION_OF dantrolene
Subject
Cells
Predicate
LOCATION_OF
Object
dantrolene
13. Organ LOCATION_OF dantrolene
Subject
Organ
Predicate
LOCATION_OF
Object
dantrolene
14. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
15. calcium ion ASSOCIATED_WITH Multiple Organ Failure
Subject
calcium ion
Predicate
ASSOCIATED_WITH
Object
Multiple Organ Failure
16. calcium ion ASSOCIATED_WITH Septicemia
Subject
calcium ion
Predicate
ASSOCIATED_WITH
Object
Septicemia
17. calcium ion ASSOCIATED_WITH Septic Shock
Subject
calcium ion
Predicate
ASSOCIATED_WITH
Object
Septic Shock
18. Septic Shock PROCESS_OF Patients
Subject
Septic Shock
Predicate
PROCESS_OF
Object
Patients
19. Ryanodine TREATS Multiple Organ Failure
Subject
Ryanodine
Predicate
TREATS
Object
Multiple Organ Failure
20. Ryanodine TREATS Systemic Inflammatory Response Syndrome
Subject
Ryanodine
Predicate
TREATS
Object
Systemic Inflammatory Response Syndrome
21. Inhibitor ASSOCIATED_WITH Septicemia
Subject
Inhibitor
Predicate
ASSOCIATED_WITH
Object
Septicemia
22. Inhibitor ASSOCIATED_WITH Septic Shock
Subject
Inhibitor
Predicate
ASSOCIATED_WITH
Object
Septic Shock
23. dantrolene TREATS Septicemia
Subject
dantrolene
Predicate
TREATS
Object
Septicemia
24. dantrolene TREATS Septic Shock
Subject
dantrolene
Predicate
TREATS
Object
Septic Shock
25. Cells LOCATION_OF dantrolene
Subject
Cells
Predicate
LOCATION_OF
Object
dantrolene
26. Organ LOCATION_OF dantrolene
Subject
Organ
Predicate
LOCATION_OF
Object
dantrolene
ABSTRACT

OBJECTIVE:

Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Calcium Channel Blockers / Sepsis / Dantrolene / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Eurrev_202104_25569

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Calcium Channel Blockers / Sepsis / Dantrolene / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2021 Document Type: Article Affiliation country: Eurrev_202104_25569