Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.
Eur Rev Med Pharmacol Sci
; 25(7): 3136-3144, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1194855
ABSTRACT
OBJECTIVE:
Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Calcium Channel Blockers
/
Sepsis
/
Dantrolene
/
COVID-19 Drug Treatment
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
Pharmacology
/
Toxicology
Year:
2021
Document Type:
Article
Affiliation country:
Eurrev_202104_25569
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