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Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19.
Harrington, Whitney E; Trakhimets, Olesya; Andrade, Daniela V; Dambrauskas, Nicholas; Raappana, Andrew; Jiang, Yonghou; Houck, John; Selman, William; Yang, Ashton; Vigdorovich, Vladimir; Yeung, Winnie; Haglund, Micaela; Wallner, Jackson; Oldroyd, Alyssa; Hardy, Samantha; Stewart, Samuel W A; Gervassi, Ana; Van Voorhis, Wes; Frenkel, Lisa; Sather, D Noah.
  • Harrington WE; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Trakhimets O; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.
  • Andrade DV; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Dambrauskas N; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Raappana A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Jiang Y; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Houck J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Selman W; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Yang A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Vigdorovich V; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Yeung W; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Haglund M; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Wallner J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Oldroyd A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Hardy S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Stewart SWA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Gervassi A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Van Voorhis W; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
  • Frenkel L; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109, USA.
  • Sather DN; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
Cell Rep Med ; 2(4): 100253, 2021 04 20.
Article in English | MEDLINE | ID: covidwho-1195473
ABSTRACT
The fate of protective immunity following mild severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection remains ill defined. Here, we characterize antibody responses in a cohort of participants recovered from mild SARS-CoV-2 infection with follow-up to 6 months. We measure immunoglobulin A (IgA), IgM, and IgG binding and avidity to viral antigens and assess neutralizing antibody responses over time. Furthermore, we correlate the effect of fever, gender, age, and time since symptom onset with antibody responses. We observe that total anti-S trimer, anti-receptor-binding domain (RBD), and anti-nucleocapsid protein (NP) IgG are relatively stable over 6 months of follow-up, that anti-S and anti-RBD avidity increases over time, and that fever is associated with higher levels of antibodies. However, neutralizing antibody responses rapidly decay and are strongly associated with declines in IgM levels. Thus, while total antibody against SARS-CoV-2 may persist, functional antibody, particularly IgM, is rapidly lost. These observations have implications for the duration of protective immunity following mild SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin M / Antibodies, Neutralizing / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100253

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin M / Antibodies, Neutralizing / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100253