The therapeutic effect and safety of the drugs for COVID-19: A systematic review and meta-analysis.
Medicine (Baltimore)
; 100(16): e25532, 2021 Apr 23.
Article
in English
| MEDLINE | ID: covidwho-1195755
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) has spread almost all regions of the world and caused great loss to the whole body of mankind. Thus, numerous clinical trials were conducted to find specific medicine for COVID-19 recently. However, it remains unanswered whether they are beneficial.OBJECTIVE:
This study aimed to evaluate the efficiency and safety of the COVID-19 medicine.METHODS:
Studies were determined through searching PubMed, Embase, Cochrane Library, and Medline. The studies of COVID-19 medicine were involved with eligible end points containing mortality, discharge rate, rate of clinical improvement, and rate of serious adverse events.RESULTS:
A total of 33 studies involving 37,879 patients were included in our study, whose intervening measures contained three major types of COVID-19 medicine, ACEI/ARB, antiviral medicine, and chloroquine/hydroxychloroquine. Compared to control group, COVID-19 drugs have no distinct effect on mortality (RR, 0.93; 95% CI, 0.79-1.11, Pâ=â.43) and discharge rate (RR, 1.06; 95% CI, 0.98-1.14, Pâ=â.13). However, antiviral medicine presents the obvious advantage in clinical improvement (RR, 1.11; 95% CI, 1.01-1.23, Pâ<â.05). In addition, the serious adverse events rate (RR, 0.75; 95% CI, 0.63-0.88, Pâ<â.05) of COVID-19 medicine is lower than control group.CONCLUSION:
The results indicated antiviral medicine was potential specific medicine for COVID-19 treatment by improving clinical symptoms, but it failed to increase the discharge rate and reduce mortality. Chloroquine/hydroxychloroquine and ACEI/ARB had no significant effect on treatment of COVID-19, thus they were not recommended for routine medication. Moreover, more trials are needed to find effective drugs to lower the mortality of COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Medicine (Baltimore)
Year:
2021
Document Type:
Article
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