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Stress Response Is the Main Trigger of Sporadic Amyloidoses.
Galkin, Alexey P; Sysoev, Evgeniy I.
  • Galkin AP; St. Petersburg Branch, Vavilov Institute of General Genetics, 199034 St. Petersburg, Russia.
  • Sysoev EI; Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Int J Mol Sci ; 22(8)2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-1196033
Semantic information from SemMedBD (by NLM)
1. Anabolism AFFECTS Disease
Subject
Anabolism
Predicate
AFFECTS
Object
Disease
2. Malignant Neoplasms COEXISTS_WITH Amyloidosis
Subject
Malignant Neoplasms
Predicate
COEXISTS_WITH
Object
Amyloidosis
3. Metabolic Diseases COEXISTS_WITH Amyloidosis
Subject
Metabolic Diseases
Predicate
COEXISTS_WITH
Object
Amyloidosis
4. Wounds and Injuries COEXISTS_WITH Amyloidosis
Subject
Wounds and Injuries
Predicate
COEXISTS_WITH
Object
Amyloidosis
5. Chronic infectious disease COEXISTS_WITH Amyloidosis
Subject
Chronic infectious disease
Predicate
COEXISTS_WITH
Object
Amyloidosis
6. Oxidative Stress COEXISTS_WITH Amyloidosis
Subject
Oxidative Stress
Predicate
COEXISTS_WITH
Object
Amyloidosis
7. COVID-19 COEXISTS_WITH Amyloidosis
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Amyloidosis
8. biological adaptation to stress AFFECTS Amyloidogenesis
Subject
biological adaptation to stress
Predicate
AFFECTS
Object
Amyloidogenesis
9. Communicable Diseases PREDISPOSES Amyloidosis
Subject
Communicable Diseases
Predicate
PREDISPOSES
Object
Amyloidosis
10. Anabolism AFFECTS Disease
Subject
Anabolism
Predicate
AFFECTS
Object
Disease
11. Malignant Neoplasms COEXISTS_WITH Amyloidosis
Subject
Malignant Neoplasms
Predicate
COEXISTS_WITH
Object
Amyloidosis
12. Metabolic Diseases COEXISTS_WITH Amyloidosis
Subject
Metabolic Diseases
Predicate
COEXISTS_WITH
Object
Amyloidosis
13. Wounds and Injuries COEXISTS_WITH Amyloidosis
Subject
Wounds and Injuries
Predicate
COEXISTS_WITH
Object
Amyloidosis
14. Chronic infectious disease COEXISTS_WITH Amyloidosis
Subject
Chronic infectious disease
Predicate
COEXISTS_WITH
Object
Amyloidosis
15. Oxidative Stress COEXISTS_WITH Amyloidosis
Subject
Oxidative Stress
Predicate
COEXISTS_WITH
Object
Amyloidosis
16. COVID-19 COEXISTS_WITH Amyloidosis
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Amyloidosis
17. biological adaptation to stress AFFECTS Amyloidogenesis
Subject
biological adaptation to stress
Predicate
AFFECTS
Object
Amyloidogenesis
18. Communicable Diseases PREDISPOSES Amyloidosis
Subject
Communicable Diseases
Predicate
PREDISPOSES
Object
Amyloidosis
ABSTRACT
Amyloidoses are a group of diseases associated with the formation of pathological protein fibrils with cross-ß structures. Approximately 5-10% of the cases of these diseases are determined by amyloidogenic mutations, as well as by transmission of infectious amyloids (prions) between organisms. The most common group of so-called sporadic amyloidoses is associated with abnormal aggregation of wild-type proteins. Some sporadic amyloidoses are known to be induced only against the background of certain pathologies, but in some cases the cause of amyloidosis is unclear. It is assumed that these diseases often occur by accident. Here we present facts and hypotheses about the association of sporadic amyloidoses with vascular pathologies, trauma, oxidative stress, cancer, metabolic diseases, chronic infections and COVID-19. Generalization of current data shows that all sporadic amyloidoses can be regarded as a secondary event occurring against the background of diseases provoking a cellular stress response. Various factors causing the stress response provoke protein overproduction, a local increase in the concentration or modifications, which contributes to amyloidogenesis. Progress in the treatment of vascular, metabolic and infectious diseases, as well as cancers, should lead to a significant reduction in the risk of sporadic amyloidoses.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Stress, Physiological / Amyloidosis Subject: Stress, Physiological / Amyloidosis Language: English Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Stress, Physiological / Amyloidosis Subject: Stress, Physiological / Amyloidosis Language: English Clinical aspect: Etiology Year: 2021
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