Animal models used in the research and development of treatments and vaccines against COVID-19
Romanian Archives of Microbiology and Immunology
; 79(3):187-194, 2020.
Article
in English
| CAB Abstracts | ID: covidwho-1196216
ABSTRACT
The purpose of this review is to carry out an overall evaluation of the scientific literature on the selection of the best candidate as an animal translation model. We used the PubMed/MEDLINE, Web of Science Core Collection and medRxiv/BioRxiv (preprint materials) databases for original research published in English to September 2020. Review research was conducted in accordance with the preferred reporting elements for systematic reviews and meta-analysis (PRISMA). The inclusion criteria were establishing animal models (mouse, ferret, dog, cat, primates, etc.) for SARS-CoV-2, prophylaxis, therapy and vaccines. The exclusion criteria were books, guidelines and protocols, population genetics. This review highlights the distinct advantages and limitations of each animal model, which should be taken into account in the design of studies, the interpretation of pathogenic mechanisms or extrapolation of the results of therapy or vaccines in humans. In order to generate results that are consistent, reproducible and comparable between studies, it is necessary to harmonize the protocols for experimentation on animal models.
Search on Google
Collection:
Databases of international organizations
Database:
CAB Abstracts
Topics:
Vaccines
Language:
English
Journal:
Romanian Archives of Microbiology and Immunology
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS