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Delivery in pregnant women infected with SARS-CoV-2: A fast review.
Parazzini, Fabio; Bortolus, Renata; Mauri, Paola Agnese; Favilli, Alessandro; Gerli, Sandro; Ferrazzi, Enrico.
  • Parazzini F; Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Bortolus R; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
  • Mauri PA; Verona University Hospital, Verona, Italy.
  • Favilli A; Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Gerli S; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
  • Ferrazzi E; Department of Obstetrics and Gynecology, AOUI Verona, Verona, Italy.
Int J Gynaecol Obstet ; 150(1): 41-46, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-1196384
ABSTRACT

BACKGROUND:

Few case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered.

OBJECTIVE:

To review the available information on mode of delivery, vertical/peripartum transmission, and neonatal outcome in pregnant women infected with SARS-CoV-2. SEARCH STRATEGY Combination of the following key words COVID-19, SARS-CoV-2, and pregnancy in Embase and PubMed databases. SELECTION CRITERIA Papers reporting cases of women infected with SARS-CoV-2 who delivered. DATA COLLECTION AND

ANALYSIS:

The following was extracted author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes. MAIN

RESULTS:

In the 13 studies included, vaginal delivery was reported in 6 cases (9.4%; 95% CI, 3.5-19.3). Indication for cesarean delivery was worsening of maternal conditions in 31 cases (48.4%; 95% CI, 35.8-61.3). Two newborns testing positive for SARS-CoV-2 by real-time RT-PCR assay were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated but the RT-PCR test was negative.

CONCLUSIONS:

The rate of vertical or peripartum transmission of SARS-CoV-2 is low, if any, for cesarean delivery; no data are available for vaginal delivery. Low frequency of spontaneous preterm birth and general favorable immediate neonatal outcome are reassuring.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Delivery, Obstetric / Betacoronavirus Type of study: Prognostic study / Reviews Limits: Adult / Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Int J Gynaecol Obstet Year: 2020 Document Type: Article Affiliation country: Ijgo.13166

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Delivery, Obstetric / Betacoronavirus Type of study: Prognostic study / Reviews Limits: Adult / Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Int J Gynaecol Obstet Year: 2020 Document Type: Article Affiliation country: Ijgo.13166