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Immune responses and pathogenesis in persistently PCR-positive patients with SARS-CoV-2 infection.
Yu, Hai-Bin; Wang, Wen-Jing; Tang, Shan; Chen, De-Xi; Xu, Bin.
  • Yu HB; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
  • Wang WJ; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
  • Tang S; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
  • Chen DX; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
  • Xu B; Department Two of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
J Med Virol ; 93(2): 760-765, 2021 02.
Article in English | MEDLINE | ID: covidwho-1196398
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 emerged in China in December 2019 and then rapidly spread worldwide. Why COVID-19 patients with the same clinical condition have different outcomes remains unclear. This study aimed to examine the differences in the phenotype and functions of major populations of immune cells between COVID-19 patients with same severity but different outcomes. Four common type adult inpatients with laboratory confirmed COVID-19 from Beijing YouAn Hospital, Capital Medical University were included in this study. The patients were divided into two groups based on whether or not COVID-19 polymerase chain reaction (PCR)-negative conversion occurred within 3 weeks. Peripheral blood samples were collected to compare the differences in the phenotype and functions of major populations of immune cells between the two groups of patients. The result shows that the proportions of CD3+ CD8+ CD38+ HLA-DR+ CD27- effector T killer cells generally declined, whereas that of CD3+ CD4+ CD8+ double-positive T cells (DPTs) increased in the persistently PCR-positive patients. In summary, considering the imbalance between effector T killer cells/CD3+CD4+CD8+ DPTs was a possible key factor for PCR-negative conversion in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Natural Killer T-Cells / Biological Variation, Individual / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26287

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Natural Killer T-Cells / Biological Variation, Individual / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26287