A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19).
J Med Virol
; 93(2): 1057-1069, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-1196440
ABSTRACT
To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients. A meta-analysis was carried out to identify studies on COVID-19 from 25 December 2019 to 30 April 2020. A total of 48 studies with 5829 pediatric patients were included. Children of all ages were at risk for COVID-19. The main illness classification ranged as 20% (95% confidence interval [CI] 14%-26%; I2 = 91.4%) asymptomatic, 33% (95% CI 23%-43%; I2 = 95.6%) mild and 51% (95% CI 42%-61%; I2 = 93.4%) moderate. The typical clinical manifestations were fever 51% (95% CI 45%-57%; I2 = 78.9%) and cough 41% (95% CI 35%-47%, I2 = 81.0%). The common laboratory findings were normal white blood cell 69% (95% CI 64%-75%; I2 = 58.5%), lymphopenia 16% (95% CI 11%-21%; I2 = 76.9%) and elevated creatine-kinase MB 37% (95% CI 25%-48%; I2 = 59.0%). The frequent imaging features were normal images 41% (95% CI 30%-52%; I2 = 93.4%) and ground-glass opacity 36% (95% CI 25%-47%; I2 = 92.9%). Among children under 1 year old, critical cases account for 14% (95% CI 13%-34%; I2 = 37.3%) that should be of concern. In addition, vomiting occurred in 33% (95% CI 18%-67%; I2 = 0.0%) cases that may also need attention. Pediatric patients with COVID-19 may experience milder illness with atypical clinical manifestations and rare lymphopenia. High incidence of critical illness and vomiting symptoms reward attention in children under 1 year old.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
English
Journal:
J Med Virol
Year:
2021
Document Type:
Article
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