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SARS-CoV-2 respiratory viral loads and association with clinical and biological features.
Biguenet, Adrien; Bouiller, Kevin; Marty-Quinternet, Solène; Brunel, Anne-Sophie; Chirouze, Catherine; Lepiller, Quentin.
  • Biguenet A; Service de Maladies Infectieuses, CHU Besançon, Besançon, France.
  • Bouiller K; Service de Maladies Infectieuses, CHU Besançon, Besançon, France.
  • Marty-Quinternet S; Laboratoire de Virologie, CHU Besançon, Besançon, France.
  • Brunel AS; Service de Maladies Infectieuses, CHU Besançon, Besançon, France.
  • Chirouze C; Service de Maladies Infectieuses, CHU Besançon, Besançon, France.
  • Lepiller Q; Laboratoire de Virologie, CHU Besançon, Besançon, France.
J Med Virol ; 93(3): 1761-1765, 2021 03.
Article in English | MEDLINE | ID: covidwho-1196476
ABSTRACT
To determine the distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) respiratory viral loads (VL) during the acute phase of infection and their correlation with clinical presentation and inflammation-related biomarkers. Nasopharyngeal swabs from 453 adult SARS-CoV-2-infected patients from the Department of Infectious Diseases, Besançon, France, were collected at the time of admission or consultation for reverse transcriptase polymerase chain reaction (RT-PCR) analysis. Clinical information and concentrations of biological parameters (C-reactive protein [CRP], fibrinogen, lactate dehydrogenase [LDH], prealbumin) were noticed. Mean respiratory VL homogeneously decreased from 7.2 log10 copies/ml (95% confidence interval [CI] 6.6-7.8) on the first day of symptoms until 4.6 log10 copies/ml (95% CI 3.8-5.4) at day 10 (slope = -0.24; R2 = .95). VL were poorly correlated with COVID-19 symptoms and outcome, excepted for dyspnea and anosmia, which were significantly associated with lower VL (p < .05). CRP, fibrinogen, and LDH concentrations significantly increased over the first 10 days (median CRP concentrations from 36.8 mg/L at days 0-1 to 99.5 mg/L at days 8-10; p < .01), whereas prealbumin concentrations tended to decrease. Since SARS-CoV-2 respiratory VL regularly decrease in the acute phase of infection, determining the level of VL may help predicting the onset of virus shedding in a specific patient. However, the role of SARS-CoV-2 VL as a biomarker of severity is limited.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Load / COVID-19 Testing / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26489

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Load / COVID-19 Testing / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26489