Your browser doesn't support javascript.
Immune response against SARS-CoV-2 in pediatric patients including young infants.
Kawamura, Yoshiki; Higashimoto, Yuki; Miura, Hiroki; Ihira, Masaru; Inaba, Masato; Ito, Ryota; Kozawa, Kei; Yoshikawa, Tetsushi.
  • Kawamura Y; Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
  • Higashimoto Y; Faculty of Medical Technology, Fujita Health University School of Health Sciences, Toyoake, Japan.
  • Miura H; Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
  • Ihira M; Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Japan.
  • Inaba M; Department of Internal Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Japan.
  • Ito R; Department of Internal Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Japan.
  • Kozawa K; Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
  • Yoshikawa T; Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
J Med Virol ; 93(3): 1776-1779, 2021 03.
Article in English | MEDLINE | ID: covidwho-1196479
ABSTRACT
Pediatric cases of the coronavirus disease 2019 (COVID-19) are generally mild or asymptomatic, and are usually detected by virological examination following close contact with COVID-19 patients, often the children's parents. The detailed clinical features and virological data of pediatric patients with COVID-19, particularly young infants, remain unclear. Here, the clinical and virological characteristics of four children with COVID-19 including two young infants were investigated. One- and 4-month-old boys with COVID-19 were both asymptomatic, and seroconversion was demonstrated. These findings suggest that even young infants can mount an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), despite having weaker immune defenses than adolescents and adults. Three-year-old boy, who was SARS-CoV-2-negative, was admitted to the same room as his SARS-CoV-2-positive father due to the lack of caregivers. Although he was asymptomatic, he had seroconverted to SARS-CoV-2. Eleven-year-old boy, who was sibling of the 3-year-old boy, was also SARS-CoV-2-negative. He was isolated in his own room and did not seroconvert. If young children are SARS-CoV-2 negative, they should be isolated from their SARS-CoV-2-positive parents. This may be difficult in practice, if parents with COVID-19 are the only available caregivers. In such situations, the most appropriate measures should be taken for each patient.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Diseases / Seroconversion / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26493

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Diseases / Seroconversion / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26493