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Combination therapy with plasma exchange and glucocorticoid may be effective for severe COVID-19 infection: A retrospective observational study.
Matsushita, Yasushi; Kusaoi, Makio; Hiki, Makoto; Murayama, Goh; Abe, Yoshiyuki; Nozawa, Kazuhisa; Takahashi, Kazuhisa; Yamaji, Ken; Tamura, Naoto; Naito, Toshio.
  • Matsushita Y; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Kusaoi M; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Hiki M; Department of Emergency Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Murayama G; Department of Cardiovascular Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Abe Y; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Nozawa K; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Takahashi K; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Yamaji K; Department of Respiratory Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Tamura N; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Naito T; Department of Internal Medicine and Rheumatology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Ther Apher Dial ; 25(4): 390-400, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1197083
ABSTRACT
We retrospectively analyzed the characteristics and outcomes of five patients with COVID-19 who were received glucocorticoid (with or without pulse therapy) and therapeutic plasma exchange. The efficacy of the treatment was determined by whether the patient was able to be transferred from the COVID-19 exclusive ICU to the general ward. In comparing patients who received prednisolone pulse therapy (three cases) with those who did not (two cases), 2/3 (66%) and 0/2 (0%) patients could be discharged from the COVID-19 dedicated ICU, respectively. Among five patients who was performed plasma exchange, two elderly male patients who underwent plasma exchange as early as within 8 days of disease exacerbation survived and were able to be transferred to the general ward. This observational study indicates that plasma exchange in conjunction with methylprednisolone pulse therapy at the appropriate time may be an effective treatment for elderly patients with severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Exchange / SARS-CoV-2 / COVID-19 / Glucocorticoids Type of study: Case report / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Ther Apher Dial Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: 1744-9987.13656

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Exchange / SARS-CoV-2 / COVID-19 / Glucocorticoids Type of study: Case report / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Ther Apher Dial Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: 1744-9987.13656