Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature.
Skelet Muscle
; 11(1): 10, 2021 04 21.
Article
in English
| MEDLINE | ID: covidwho-1197351
ABSTRACT
BACKGROUND:
SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakness or even ventilatory failure. CASE PRESENTATION We addressed such a patient in his forties presented with features of severe SARS-CoV2 pneumonia and high serum CPK. He developed severe sepsis and acute respiratory distress syndrome (ARDS) and received intravenous high dose corticosteroid and tocilizumab to counter SARS-CoV2 associated cytokine surge. After 10 days of mechanical ventilation (MV), weaning was unsuccessful albeit apparently clear lung fields, having additionally severe and symmetric limb muscle weakness. Ancillary investigations in addition with serum CPK, including electromyogram, muscle biopsy, and muscle magnetic resonance imaging (MRI) suggested acute myopathy possibly due to skeletal myositis.CONCLUSION:
We wish to stress that myopathogenic medication in SARS-CoV2 pneumonia should be used with caution. Additionally, serum CPK could be a potential marker to predict respiratory failure in SARS-CoV2 pneumonia as skeletal myopathy affecting chest muscles may contribute ventilatory failure on top of oxygenation failure due to SARS-CoV2 pneumonia.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Quadriplegia
/
Respiratory Distress Syndrome
/
Muscle, Skeletal
/
Creatine Kinase
/
COVID-19
/
Muscular Diseases
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Skelet Muscle
Year:
2021
Document Type:
Article
Affiliation country:
S13395-021-00266-5
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