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Colorimetric isothermal nucleic acid detection of SARS-CoV-2 with dye combination.
Wu, Shanshan; Liu, Xiyang; Ye, Shenglong; Liu, Jianmin; Zheng, Wei; Dong, Xue; Yin, Xiushan.
  • Wu S; Applied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, 110142, Shenyang, China.
  • Liu X; Biotech & Biomedicine Science (Shenyang) Co. Ltd, Shenyang, 110000, China.
  • Ye S; Biotech & Biomedicine Science (Shenyang) Co. Ltd, Shenyang, 110000, China.
  • Liu J; Shenyang Center for Disease Control and Prevention, 110031, Shenyang, Liaoning, China.
  • Zheng W; Liaoning Cancer Hospital and Institute, No. 44 Xiaoheyan Rd, Dadong District, ShenYang, 110042 China.
  • Dong X; Shenyang Center for Disease Control and Prevention, 110031, Shenyang, Liaoning, China.
  • Yin X; Applied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, 110142, Shenyang, China.
Heliyon ; 7(4): e06886, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1198767
ABSTRACT
RT-LAMP detection of SARS-CoV-2 has been demonstrated to be a valuable diagnostic method for the diagnosis of COVID-191,2, which can rapidly screen carriers of the virus to effectively control the spread of the SARS-CoV-2. Here, we present a combination of dyes for isothermal detection of SARS-CoV-2 as a commercial alternative, with expanded colorimetric spectrum. We compared them with commercial reagents and proved their suitability and sensitivity through clinical RNA samples. In addition, together with commercial single dye indicators, we believe the expanded color spectrum developed here as an indicator of rapid detection will promote the diagnosis of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Journal: Heliyon Year: 2021 Document Type: Article Affiliation country: J.heliyon.2021.e06886

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Journal: Heliyon Year: 2021 Document Type: Article Affiliation country: J.heliyon.2021.e06886