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Evaluation of hepatic enzymes activities in COVID-19 patients.
Hwaiz, Rundk; Merza, Mohammed; Hamad, Badraldin; HamaSalih, Shirin; Mohammed, Mustafa; Hama, Harmand.
  • Hwaiz R; Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Kurdistan, Iraq; Medical Analysis Department, Faculty of Science, Tishk International University, Erbil, Kurdistan, Iraq.
  • Merza M; Clinical Analysis Department, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq; Medical Analysis Department, Faculty of Science, Tishk International University, Erbil, Kurdistan, Iraq. Electronic address: mohammed.merza@hmu.edu.krd.
  • Hamad B; Pharmacology Department, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
  • HamaSalih S; Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Kurdistan, Iraq.
  • Mohammed M; Ministry of Health/Corona Centre, Kurdistan, Iraq.
  • Hama H; Biology Department, Faculty of Education, Tishk International University, Erbil, Kurdistan, Iraq.
Int Immunopharmacol ; 97: 107701, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1198830
ABSTRACT
SARS-CoV-2 or Coronavirus disease 2019 (COVID-19) outbreak which caused by the severe acute respiratory syndrome, has rapidly spread over the world. The exact mechanism how this virus will affect the liver remained elusive. The aim of this study was to evaluate the liver function in patients with severe acute respiratory syndrome coronavirus 2 and potential causes of hepatic enzymes disease in these patients. Clinical characteristics and laboratory findings were collected from patients with COVID-19 who were admitted to the corona center in Erbil city/Kurdistan region of Iraq, from March 10 to July 10, 2020. Serum was collected from patients with COVID-19 and liver enzyme tests were measured. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL) were analyzed in these patients. Of the 74 patients, 25 (34.7%) had abnormal ALT activity, 28 (40%) had abnormal AST activity, 12 (20.3%) had abnormal ALP activity, and 39 (52.7%) had abnormal total bilirubin P-value < 0.05. The inflammatory biomarkers CRP and IL-6 in COVID-19 patients with abnormal liver function test (4.9 ± 1.0 mg/dl) and (231.2 ± 35.7 pg/ml) respectively. The levels of both biomarkers were statistically significantly higher than COVID-19 patients with normal liver function test (2.1 ± 0.5 mg/dl) and (2.1 ± 0.5 mg/dl) respectively, P-value < 0.05. However, CRP and IL-6 were not statistically significant different between male and female COVID-19 patients P-value < 0.05. In conclusion, we found that most of the patients with SARS-CoV-2 have abnormal hepatic enzyme activities and that is might related to virus replication in the liver.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article Affiliation country: J.intimp.2021.107701

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article Affiliation country: J.intimp.2021.107701