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Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome.
Chen, Luke Y C; Biggs, Catherine M; Jamal, Shahin; Stukas, Sophie; Wellington, Cheryl L; Sekhon, Mypinder S.
  • Chen LYC; Division of Hematology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
  • Biggs CM; Centre for Health Education Scholarship, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
  • Jamal S; Division of Allergy and Immunology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
  • Stukas S; Division of Rheumatology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
  • Wellington CL; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
  • Sekhon MS; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
Cell Rep Med ; 2(5): 100269, 2021 05 18.
Article in English | MEDLINE | ID: covidwho-1199129
ABSTRACT
Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Interleukin-6 / Cytokine Release Syndrome / COVID-19 Type of study: Diagnostic study Topics: Long Covid Limits: Humans Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100269

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Interleukin-6 / Cytokine Release Syndrome / COVID-19 Type of study: Diagnostic study Topics: Long Covid Limits: Humans Language: English Journal: Cell Rep Med Year: 2021 Document Type: Article Affiliation country: J.xcrm.2021.100269